Literature DB >> 1632833

Inhibition of transketolase and pyruvate decarboxylase by omeprazole.

P F Nixon1, R J Diefenbach, R G Duggleby.   

Abstract

Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki value of 42 +/- 3 microM, whereas inhibition of TK was complex.

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Year:  1992        PMID： 1632833     DOI： 10.1016/0006-2952(92)90053-l

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  5 in total

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Review 5.  Hiding in Plain Sight: Modern Thiamine Deficiency.

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  5 in total

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