Literature DB >> 1632790

Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol.

G Melnykovych1, J S Haug, C M Goldner.   

Abstract

Acute leukemia cells of the established line CEM-C1 were treated during growth in serum-free medium with various concentrations of trans-trans farnesol. At concentrations ranging from 9.0 to 31.5 microM, farnesol inhibited growth of these cells without causing cell lysis. This effect was preceded by very rapid inhibition of choline incorporation in cellular lipid fraction. The growth inhibitory effect was prevented to a large extent by incubation with phosphatidylcholine or diacylglycerol.

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Year:  1992        PMID： 1632790     DOI： 10.1016/s0006-291x(05)80842-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells.

Authors:  Joung Hyuck Joo; Eiichiro Ueda; Carl D Bortner; Xiao-Ping Yang; Grace Liao; Anton M Jetten
Journal:  Biochem Pharmacol       Date:  2015-08-11       Impact factor: 5.858

2.  Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha).

Authors:  Thomas A Lagace; Neale D Ridgway
Journal:  Biochem J       Date:  2005-12-15       Impact factor: 3.857

3.  An Approach to Minimize Tumour Proliferation by Reducing the Formation of Components for Cell Membrane.

Authors:  Inmaculada de Dios-Pérez; Álvaro González-Garcinuño; Eva María Martín Del Valle
Journal:  Molecules       Date:  2022-04-24       Impact factor: 4.927

4.  Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae.

Authors:  K Machida; T Tanaka; K Fujita; M Taniguchi
Journal:  J Bacteriol       Date:  1998-09       Impact factor: 3.490

5.  Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity.

Authors:  P A Voziyan; C M Goldner; G Melnykovych
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857

Review 6.  Molecular mechanisms involved in farnesol-induced apoptosis.

Authors:  Joung Hyuck Joo; Anton M Jetten
Journal:  Cancer Lett       Date:  2009-06-10       Impact factor: 8.679

Review 7.  Lipid composition of the cancer cell membrane.

Authors:  Wojciech Szlasa; Iga Zendran; Aleksandra Zalesińska; Mounir Tarek; Julita Kulbacka
Journal:  J Bioenerg Biomembr       Date:  2020-07-26       Impact factor: 2.945

8.  Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Authors:  Anke J Roelofs; Claire M Edwards; R Graham G Russell; F Hal Ebetino; Michael J Rogers; Philippa A Hulley
Journal:  J Pharmacol Exp Ther       Date:  2007-04-05       Impact factor: 4.030
  8 in total

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