Literature DB >> 16327899

A diversity oriented four-component approach to tetrahydro-beta-carbolines initiated by Sonogashira coupling.

Alexei S Karpov1, Frank Rominger, Thomas J J Müller.   

Abstract

A consecutive four-component synthesis of highly-substituted tetrahydro-beta-carbolines can be achieved by a coupling-aminatio-aza-annulation-Pictet-Spengler (CAAPS) sequence creating five new sigma-bonds and four new stereocenters in a one-pot fashion. The structures were unambiguously supported by X-ray structure analyses.

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Year:  2005        PMID： 16327899     DOI： 10.1039/b511861a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  Aza-Annulation of 1,2,3,4-Tetrahydro-β-carboline Derived Enaminones and Nitroenamines: Synthesis of Functionalized Indolizino[8,7-b]indoles, Pyrido[1,2-a:3,4-b']diindoles, Indolo[2,3-a]quinolizidine-4-ones and Other Tetrahydro-β-carboline Fused Heterocycles.

Authors:  Anusha Avadhani; Pethaperumal Iniyavan; Anand Acharya; Vibha Gautam; Sriparna Chakrabarti; Hiriyakkanavar Ila
Journal:  ACS Omega       Date:  2019-10-16

2.  Convenient construction of tetrahydrochromeno[4',3':2,3]indolizino[8,7-b]indoles and tetrahydroindolizino[8,7-b]indoles via one-pot domino reaction.

Authors:  Jing Sun; Wang Jiang; Chao-Guo Yan
Journal:  RSC Adv       Date:  2018-08-14       Impact factor: 3.361
  2 in total

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