Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates.

Literature DB >> 16326106

Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates.

Chunshen Zhao¹, Yanfang Zhao, Huifang Chai, Ping Gong.

Abstract

A series of ethyl 5-hydroxy-1H-indole-3-carboxylates 6A-10T were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities in 2.2.15 cells. The IC50 and selective index of inhibition on replication of HBV DNA of compounds 10(L) (1.52 microg/ml, 9.38) and 10(P) (2.00 microg/ml, 8.85) were higher than those of the other evaluated compounds including lamivudine (7.02). Compounds 7E and 10J exhibited significant anti-HBV activities, and the IC50 values on replication of HBV DNA of these compounds were 24.90 and 15.41 microg/ml, respectively, which were far more potent than the positive control lamivudine 228.00 microg/ml.

Entities: Chemical Species

Mesh：

Substances：
Antiviral Agents
Indoles

Year: 2005 PMID： 16326106 DOI： 10.1016/j.bmc.2005.11.033

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

Keyword Cloud
Cited

13 in total

10. Pharmacokinetic properties and bioequivalence of two formulations of arbidol: an open-label, single-dose, randomized-sequence, two-period crossover study in healthy Chinese male volunteers.

Authors: Ming-Yan Liu; Shuang Wang; Wei-Fan Yao; Hui-zhe Wu; Sheng-Nan Meng; Min-Jie Wei
Journal: Clin Ther Date: 2009-04 Impact factor: 3.393

Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates.

Review 1. Computational methods in drug discovery.

2. Identification of novel 5-hydroxy-1H-indole-3-carboxylates with anti-HBV activities based on 3D QSAR studies.

3. The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses.

Review 4. Mannich bases in medicinal chemistry and drug design.

Review 5. Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis.

Review 6. Discovery and development of anti-HBV agents and their resistance.

7. Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.

Review 8. New Approaches and Repurposed Antiviral Drugs for the Treatment of the SARS-CoV-2 Infection.

9. The Antiviral Drug Arbidol Inhibits Zika Virus.

10. Pharmacokinetic properties and bioequivalence of two formulations of arbidol: an open-label, single-dose, randomized-sequence, two-period crossover study in healthy Chinese male volunteers.