OBJECTIVE: We studied a large cohort of identical twin sisters, utilizing the unique properties of a twin research design to explore the relationship between obstetrical delivery mode and stress urinary incontinence. STUDY DESIGN: An anonymous 67-item survey was completed by 271 identical twin pairs (n = 542) at the world's largest annual gathering of twins. Logistic regression for repeated binary measures was used to evaluate risk factors and accounting for shared genetics within pairs. RESULTS: The twins had a mean age of 47.1 years (range 15 to 85 years), and stress urinary incontinence was reported by 51.8%. Stress urinary incontinence was associated with age (P = .001), parity (P = .001), obesity (P = .002), and birth mode, with vaginal delivery conferring a considerable increase in stress urinary incontinence risk relative to cesarean section (odds ratio 2.28, 95% confidence interval 1.14 to 4.55, P = .019). CONCLUSION: Vaginal delivery mode represents a potent determinant of stress urinary incontinence, carrying more than twice the risk of cesarean section. This study of identical twins provides new insight into the epidemiology of female incontinence.
OBJECTIVE: We studied a large cohort of identical twin sisters, utilizing the unique properties of a twin research design to explore the relationship between obstetrical delivery mode and stress urinary incontinence. STUDY DESIGN: An anonymous 67-item survey was completed by 271 identical twin pairs (n = 542) at the world's largest annual gathering of twins. Logistic regression for repeated binary measures was used to evaluate risk factors and accounting for shared genetics within pairs. RESULTS: The twins had a mean age of 47.1 years (range 15 to 85 years), and stress urinary incontinence was reported by 51.8%. Stress urinary incontinence was associated with age (P = .001), parity (P = .001), obesity (P = .002), and birth mode, with vaginal delivery conferring a considerable increase in stress urinary incontinence risk relative to cesarean section (odds ratio 2.28, 95% confidence interval 1.14 to 4.55, P = .019). CONCLUSION: Vaginal delivery mode represents a potent determinant of stress urinary incontinence, carrying more than twice the risk of cesarean section. This study of identical twins provides new insight into the epidemiology of female incontinence.
Authors: H Q Pan; J M Kerns; D L Lin; S Liu; N Esparza; M S Damaser Journal: Am J Physiol Regul Integr Comp Physiol Date: 2007-01-04 Impact factor: 3.619
Authors: Thomas J Connolly; Heather J Litman; Sharon L Tennstedt; Carol L Link; John B McKinlay Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2007-01-12
Authors: Tondalaya L Gamble; Hongyan Du; Peter K Sand; Sylvia M Botros; Magdalena Rurak; Roger P Goldberg Journal: Int Urogynecol J Date: 2010-05-06 Impact factor: 2.894
Authors: Hai-Hong Jiang; A Marcus Gustilo-Ashby; Levilester B Salcedo; Hui Q Pan; David F Sypert; Robert S Butler; Margot S Damaser Journal: Exp Neurol Date: 2008-11-13 Impact factor: 5.330