| Literature DB >> 16325568 |
Jean-Martin Beaulieu1, Marc G Caron.
Abstract
Arrestins have important roles in the cytoplasm and at the plasma membrane, including the desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters.Entities:
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Year: 2005 PMID： 16325568 DOI： 10.1016/j.cell.2005.11.010
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582