BACKGROUND: Recent data suggest that inflammatory reactions are involved in the pathogenesis of cerebral ischaemia. AIM: To investigate whether certain inflammatory genetic polymorphisms are associated with the occurrence of ischaemic stroke. METHODS: We investigated the prevalence of six polymorphisms in cytokine genes (IL-6, TNF-alpha, TNF-beta, IL-1beta, IL-10, and IL-1Ralpha) in a group of ischaemic stroke patients (n = 105) and in a control population (n = 389). We analysed the prevalence of these polymorphisms in different stroke subtypes and in relation to outcome six months post-stroke. RESULTS: There was no significant variation in cytokine gene polymorphism frequencies between control and stroke populations or for different stroke subtypes. Subgroup analysis demonstrated that the prevalence of the IL-6 -174 CC genotype was significantly lower in stroke patients without a history of hypertension compared to controls. CONCLUSION: The IL6 -174 CC genotype may be protective against stroke in those patients who have no history of hypertension. Further studies are required to verify these findings.
BACKGROUND: Recent data suggest that inflammatory reactions are involved in the pathogenesis of cerebral ischaemia. AIM: To investigate whether certain inflammatory genetic polymorphisms are associated with the occurrence of ischaemic stroke. METHODS: We investigated the prevalence of six polymorphisms in cytokine genes (IL-6, TNF-alpha, TNF-beta, IL-1beta, IL-10, and IL-1Ralpha) in a group of ischaemic strokepatients (n = 105) and in a control population (n = 389). We analysed the prevalence of these polymorphisms in different stroke subtypes and in relation to outcome six months post-stroke. RESULTS: There was no significant variation in cytokine gene polymorphism frequencies between control and stroke populations or for different stroke subtypes. Subgroup analysis demonstrated that the prevalence of the IL-6 -174 CC genotype was significantly lower in strokepatients without a history of hypertension compared to controls. CONCLUSION: The IL6 -174 CC genotype may be protective against stroke in those patients who have no history of hypertension. Further studies are required to verify these findings.
Authors: F Burzotta; L Iacoviello; A Di Castelnuovo; F Glieca; N Luciani; R Zamparelli; R Schiavello; M B Donati; A Maseri; G Possati; F Andreotti Journal: Am J Cardiol Date: 2001-11-15 Impact factor: 2.778
Authors: Markus Nauck; Bernhard R Winkelmann; Michael M Hoffmann; Bernhard O Böhm; Heinrich Wieland; Winfried März Journal: J Mol Med (Berl) Date: 2002-06-21 Impact factor: 4.599
Authors: E Amirian; Yanhong Liu; Michael E Scheurer; Randa El-Zein; Mark R Gilbert; Melissa L Bondy Journal: Neuro Oncol Date: 2010-02-05 Impact factor: 12.300
Authors: John W Cole; David W Brown; Wayne H Giles; Oscar C Stine; Jeffrey R O'Connell; Braxton D Mitchell; John D Sorkin; Marcella A Wozniak; Barney J Stern; Mary J Sparks; Mark T Dobbins; Latasha T Shoffner; Nancy K Zappala; Laurie J Reinhart; Steven J Kittner Journal: Thromb J Date: 2008-08-26