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Literature DB >> 16323046

In silico identification and analysis of new Artemis/Artemis-like sequences from fungal and metazoan species.

Diego Bonatto¹, Martin Brendel, João Antonio Pêgas Henriques.

Abstract

The Artemis Group comprises mammalian proteins with important functions in the repair of ionizing radiation-induced DNA double-strand breaks and in the cleavage of DNA hairpin extremities generated during V(D)J recombination. Little is known about the presence of Artemis/Artemis-like proteins in non-mammalian species. We have characterized new Artemis/Artemis-like sequences from the genomes of some fungi and from non-mammalian metazoan species. An in-depth phylogenetic analysis of these new Artemis/Artemis-like sequences showed that they form a distinct clade within the Pso2p/Snm1p A and B Groups. Hydrophobic cluster analysis and three-dimensional modeling allowed to map and to compare conserved regions in these Artemis/Artemis-like proteins. The results indicate that Artemis probably belongs to an ancient DNA recombination mechanism that diversified with the evolution of multi-cellular eukaryotic lineage.

Entities: Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16323046 DOI： 10.1007/s10930-005-7594-2

Source DB: PubMed Journal: Protein J ISSN： 1572-3887 Impact factor: 2.371

44 in total

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