Literature DB >> 16322523

The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.

Julie Douville1, Jocelyn David, Karine M Lemieux, Luc Gaudreau, Dindial Ramotar.   

Abstract

We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.

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Year:  2005        PMID： 16322523      PMCID： PMC1456220          DOI： 10.1534/genetics.105.046110

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  22 in total

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2.  Quantitation of putative activator-target affinities predicts transcriptional activating potentials.

Authors:  Y Wu; R J Reece; M Ptashne
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Authors:  B Rempola; A Kaniak; A Migdalski; J Rytka; P P Slonimski; J P di Rago
Journal:  Mol Gen Genet       Date:  2000-01

4.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

5.  Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

Authors:  C J Di Como; K T Arndt
Journal:  Genes Dev       Date:  1996-08-01       Impact factor: 11.361

6.  A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

Authors:  T F Chan; J Carvalho; L Riles; X F Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

7.  Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A.

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8.  SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1.

Authors:  M J Fernandez-Sarabia; A Sutton; T Zhong; K T Arndt
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9.  Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast.

Authors:  Tobias Schmelzle; Thomas Beck; Dietmar E Martin; Michael N Hall
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

10.  The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA.

Authors:  J Douville; J David; P-K Fortier; Dindial Ramotar
Journal:  Curr Genet       Date:  2004-05-19       Impact factor: 3.886
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  8 in total

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2.  Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

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Journal:  Genetics       Date:  2012-01-20       Impact factor: 4.562

3.  The histone H2B Arg95 residue links the pheromone response pathway to rapamycin-induced G1 arrest in yeast.

Authors:  Abdallah Alhaj Sulaiman; Reem Ali; Mustapha Aouida; Balasubramanian Moovarkumudalvan; Dindial Ramotar
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4.  TOR Facilitates the Targeting of the 19S Proteasome Subcomplex To Enhance Transcription Complex Assembly at the Promoters of the Ribosomal Protein Genes.

Authors:  Bhawana Uprety; Amala Kaja; Sukesh R Bhaumik
Journal:  Mol Cell Biol       Date:  2018-06-28       Impact factor: 4.272

5.  Rrd1 isomerizes RNA polymerase II in response to rapamycin.

Authors:  Nathalie Jouvet; Jeremie Poschmann; Julie Douville; Lisa Bulet; Dindial Ramotar
Journal:  BMC Mol Biol       Date:  2010-12-03       Impact factor: 2.946

6.  The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses.

Authors:  Jeremie Poschmann; Simon Drouin; Pierre-Etienne Jacques; Karima El Fadili; Michael Newmarch; François Robert; Dindial Ramotar
Journal:  PLoS One       Date:  2011-08-24       Impact factor: 3.240

7.  Rrd1p, an RNA polymerase II-specific prolyl isomerase and activator of phosphoprotein phosphatase, promotes transcription independently of rapamycin response.

Authors:  Rwik Sen; Shivani Malik; Sarah Frankland-Searby; Bhawana Uprety; Shweta Lahudkar; Sukesh R Bhaumik
Journal:  Nucleic Acids Res       Date:  2014-08-11       Impact factor: 16.971

8.  Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum.

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  8 in total

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