BACKGROUND AND PURPOSE: Cerebral infarction is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. Gretarsdottir et al identified a candidate locus (STRK1) for cerebral infarction with a significant logarithm of odds score at 5q12 in whites in 2002 and subsequently identified the PDE4D gene as a susceptibility gene at this locus in 2003. The aims of this haplotype-based case-control study were to confirm, using microsatellite markers and single-nucleotide polymorphisms (SNPs), whether PDE4D is also a susceptibility gene for cerebral infarction in Japanese subjects. METHODS: Cerebral infarction was defined as noncardiogenic ischemic stroke with signs and symptoms lasting >1 month in duration. We genotyped 208 Japanese cerebral infarction patients and 270 non-cerebral infarction controls for 31 SNPs, 3 dinucleotide microsatellites, and 1 tetranucleotide variable number of tandem repeat. Haplotypes were constructed and their frequencies compared between the cerebral infarction patients and the controls. RESULTS: The haplotype-based case-control study revealed that in addition to the region of the PDE4D gene (P=0.002), another region (P<0.001) also existed within the STRK1 locus. CONCLUSIONS: The region of the PDE4D gene and the other newly detected region within the STRK1 locus were associated with cerebral infarction.
BACKGROUND AND PURPOSE:Cerebral infarction is thought to be a multifactorial disease that is affected by several environmental factors and genetic variants. Gretarsdottir et al identified a candidate locus (STRK1) for cerebral infarction with a significant logarithm of odds score at 5q12 in whites in 2002 and subsequently identified the PDE4D gene as a susceptibility gene at this locus in 2003. The aims of this haplotype-based case-control study were to confirm, using microsatellite markers and single-nucleotide polymorphisms (SNPs), whether PDE4D is also a susceptibility gene for cerebral infarction in Japanese subjects. METHODS:Cerebral infarction was defined as noncardiogenic ischemic stroke with signs and symptoms lasting >1 month in duration. We genotyped 208 Japanese cerebral infarctionpatients and 270 non-cerebral infarction controls for 31 SNPs, 3 dinucleotide microsatellites, and 1 tetranucleotide variable number of tandem repeat. Haplotypes were constructed and their frequencies compared between the cerebral infarctionpatients and the controls. RESULTS: The haplotype-based case-control study revealed that in addition to the region of the PDE4D gene (P=0.002), another region (P<0.001) also existed within the STRK1 locus. CONCLUSIONS: The region of the PDE4D gene and the other newly detected region within the STRK1 locus were associated with cerebral infarction.
Authors: Håkan Lövkvist; Sandra Olsson; Peter Höglund; Olle Melander; Christina Jern; Marketa Sjögren; Gunnar Engström; J Gustav Smith; Bo Hedblad; Gunnar Andsberg; Hossein Delavaran; Katarina Jood; Ulf Kristoffersson; Holger Luthman; Bo Norrving; Arne Lindgren Journal: Eur J Hum Genet Date: 2012-01-25 Impact factor: 4.246
Authors: Mar Matarin; Javier Simon-Sanchez; Hon-Chung Fung; Sonja Scholz; J Raphael Gibbs; Dena G Hernandez; Cynthia Crews; Angela Britton; Fabienne Wavrant De Vrieze; Thomas G Brott; Robert D Brown; Bradford B Worrall; Scott Silliman; L Douglas Case; John A Hardy; Stephen S Rich; James F Meschia; Andrew B Singleton Journal: Neurogenetics Date: 2008-02-21 Impact factor: 2.660
Authors: J M Staton; M S Sayer; G J Hankey; J Attia; A Thakkinstian; Q Yi; V J Cole; R Baker; J W Eikelboom Journal: J Neurol Neurosurg Psychiatry Date: 2006-09 Impact factor: 10.154
Authors: Qing Song; John W Cole; Jeffrey R O'Connell; Oscar C Stine; Margaret Gallagher; Wayne H Giles; Braxton D Mitchell; Marcella A Wozniak; Barney J Stern; John D Sorkin; Patrick F McArdle; Adam C Naj; Qin Xu; Gary H Gibbons; Steven J Kittner Journal: Hum Mol Genet Date: 2006-07-11 Impact factor: 6.150
Authors: Lynda D Lisabeth; Patricia A Peyser; Jeffrey C Long; Jennifer J Majerisk; Melinda A Smith; Lewis B Morgenstern Journal: Neuroepidemiology Date: 2008-06-06 Impact factor: 3.282