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Literature DB >> 16322

Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine.

Abstract

The inhibition by naloxone of tolerance and dependence in morphinized mice is dose- and time-dependent. In animals receiving a single, large dose of morphine, partial inhibition by naloxone of the analgesic effect results in partial development of tolerance and dependence. This relationship appears to be true for animals which have been treated with morphine chronically. Complete and sustained blockage of morphine receptors by naloxone is required for complete inhibition of the development of tolerance and dependence.

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Year: 1977 PMID： 16322

Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164

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Cited

17 in total

Review 1. Acute opioid dependence: characterizing the early adaptations underlying drug withdrawal.

Authors: Andrew C Harris; Jonathan C Gewirtz
Journal: Psychopharmacology (Berl) Date: 2005-02-05 Impact factor: 4.530

2. Haloperidol disrupts opioid-antinociceptive tolerance and physical dependence.

Authors: Cheng Yang; Yan Chen; Lei Tang; Zaijie Jim Wang
Journal: J Pharmacol Exp Ther Date: 2011-03-24 Impact factor: 4.030

3. Opioid physical dependence development in humans: effect of time between agonist pretreatments.

Authors: K C Kirby; M L Stitzer
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

4. Methysergide and metergoline reduce morphine analgesia with no effect on the development of tolerance in rats.

Authors: S Romandini; R Samanin
Journal: Psychopharmacology (Berl) Date: 1984 Impact factor: 4.530

5. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

Authors: S M Crain; K F Shen
Journal: Proc Natl Acad Sci U S A Date: 1995-11-07 Impact factor: 11.205

6. Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.

Authors: Yan Zhang; Amanda Braithwaite; Yunyun Yuan; John M Streicher; Edward J Bilsky
Journal: Eur J Pharmacol Date: 2014-05-08 Impact factor: 4.432

Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine.

Review 1. Acute opioid dependence: characterizing the early adaptations underlying drug withdrawal.

2. Haloperidol disrupts opioid-antinociceptive tolerance and physical dependence.

3. Opioid physical dependence development in humans: effect of time between agonist pretreatments.

4. Methysergide and metergoline reduce morphine analgesia with no effect on the development of tolerance in rats.

5. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

6. Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.

7. An electromyographic method for the assessment of naloxone-induced abstinence in morphine-dependent rats.

8. Pharmacological characterization of opiate physical dependence in the isolated ileum of the guinea-pig.

9. Naloxone prevention of morphine LDR curve flattening associated with high-dose tolerance.

10. Naloxone pretreatment blocks acute morphine-induced sensitization to naltrexone.