Literature DB >> 16321959

An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.

Paula Sachelaru1, Emile Schiltz, Gabor L Igloi, Roderich Brandsch.   

Abstract

The enzyme catalyzing the hydrolytic cleavage of 2,6-dihydroxypseudooxynicotine to 2,6-dihydroxypyridine and gamma-N-methylaminobutyrate was found to be encoded on pAO1 of Arthrobacter nicotinovorans. The new enzyme answers an old question about nicotine catabolism and may be the first C--C bond hydrolase that is involved in the biodegradation of a heterocyclic compound.

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Year:  2005        PMID： 16321959      PMCID： PMC1317030          DOI： 10.1128/JB.187.24.8516-8519.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  18 in total

Review 1.  Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms.

Authors:  M Holmquist
Journal:  Curr Protein Pept Sci       Date:  2000-09       Impact factor: 3.272

2.  [6-hydroxypyridyl-(3)]-ketone].

Authors:  F A GRIES; K DECKER; H EBERWEIN; M BRUEHMUELLER
Journal:  Biochem Z       Date:  1961

3.  The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase.

Authors:  P E Holmes; S C Rittenberg
Journal:  J Biol Chem       Date:  1972-12-10       Impact factor: 5.157

4.  Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans.

Authors:  K Decker; H Bleeg
Journal:  Biochim Biophys Acta       Date:  1965-08-24

5.  The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.

Authors:  R L Gherna; S H Richardson; S C Rittenberg
Journal:  J Biol Chem       Date:  1965-09       Impact factor: 5.157

6.  Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.

Authors:  D Baitsch; C Sandu; R Brandsch; G L Igloi
Journal:  J Bacteriol       Date:  2001-09       Impact factor: 3.490

7.  A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.

Authors:  Calin B Chiribau; Cristinel Sandu; Marco Fraaije; Emile Schiltz; Roderich Brandsch
Journal:  Eur J Biochem       Date:  2004-12

8.  Sequence of the 165-kilobase catabolic plasmid pAO1 from Arthrobacter nicotinovorans and identification of a pAO1-dependent nicotine uptake system.

Authors:  Gabor L Igloi; Roderich Brandsch
Journal:  J Bacteriol       Date:  2003-03       Impact factor: 3.490

9.  Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which cleaves carbon-carbon bonds.

Authors:  E Díaz; K N Timmis
Journal:  J Biol Chem       Date:  1995-03-17       Impact factor: 5.157

10.  Sequence of the bphD gene encoding 2-hydroxy-6-oxo-(phenyl/chlorophenyl)hexa-2,4-dienoic acid (HOP/cPDA) hydrolase involved in the biphenyl/polychlorinated biphenyl degradation pathway in Comamonas testosteroni: evidence suggesting involvement of Ser112 in catalytic activity.

Authors:  D Ahmad; J Fraser; M Sylvestre; A Larose; A Khan; J Bergeron; J M Juteau; M Sondossi
Journal:  Gene       Date:  1995-04-14       Impact factor: 3.688
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  6 in total

1.  How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.

Authors:  Alissa Rauwerdink; Romas J Kazlauskas
Journal:  ACS Catal       Date:  2015-09-09       Impact factor: 13.084

2.  An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism.

Authors:  Marius Mihasan; Calin-Bogdan Chiribau; Thorsten Friedrich; Vlad Artenie; Roderich Brandsch
Journal:  Appl Environ Microbiol       Date:  2007-02-09       Impact factor: 4.792

3.  A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16.

Authors:  Hongzhi Tang; Shuning Wang; Lanying Ma; Xiangzhou Meng; Zixin Deng; Dake Zhang; Cuiqing Ma; Ping Xu
Journal:  Appl Environ Microbiol       Date:  2008-01-18       Impact factor: 4.792

4.  Characterization of a Novel Nicotine Degradation Gene Cluster ndp in Sphingomonas melonis TY and Its Evolutionary Analysis.

Authors:  Haixia Wang; Xiao-Yang Zhi; Jiguo Qiu; Longxiang Shi; Zhenmei Lu
Journal:  Front Microbiol       Date:  2017-03-09       Impact factor: 5.640

Review 5.  Current status on biochemistry and molecular biology of microbial degradation of nicotine.

Authors:  Raman Gurusamy; Sakthivel Natarajan
Journal:  ScientificWorldJournal       Date:  2013-12-29

Review 6.  The enzymes of microbial nicotine metabolism.

Authors:  Paul F Fitzpatrick
Journal:  Beilstein J Org Chem       Date:  2018-08-31       Impact factor: 2.883
  6 in total

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