| Literature DB >> 16321529 |
Kee-In Lee1, Youmie Park, Su-Jin Park, Jung-Hwan Hwang, Sung-Jin Lee, Gun-Do Kim, Woo-Kyu Park, Sunghou Lee, Daeyoung Jeong, Jae-Yang Kong, Hee-Kyoung Kang, Heeyeong Cho.
Abstract
A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.Entities:
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Year: 2006 PMID： 16321529 DOI： 10.1016/j.bmcl.2005.08.115
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823