| Literature DB >> 16321525 |
Sergio A Alonso De Diego1, Marta Gutiérrez-Rodríguez, M Jesús Pérez de Vega, Diego Casabona, Carlos Cativiela, Rosario González-Muñiz, Rosario Herranz, Edurne Cenarruzabeitia, Diana Frechilla, Joaquín Del Río, M Luisa Jimeno, M Teresa García-López.
Abstract
A suitable solid-phase approach, based on Fmoc/(t)Bu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.Entities:
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Year: 2006 PMID： 16321525 DOI： 10.1016/j.bmcl.2005.11.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823