Literature DB >> 16321377

Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats.

Stephen J Lewis1, Monica Y Bhopatkar, Tina M Walton, James N Bates.   

Abstract

This study demonstrates that the vasodilator potencies of nitric oxide (NO) donors such as sodium nitroprusside are increased in conscious Spontaneously Hypertensive (SH) as compared to Wistar Kyoto (WKY) rats. For example, the NO donors do not dilate hindlimb resistance arteries in WKY rats whereas they elicit pronounced vasodilator responses in SH rats. This study also demonstrates that the NO-mediated vasodilator responses in WKY and SH rats were markedly diminished after blockade of voltage-sensitive Ca2+-channels (CaVS2+-channels) with nifedipine, diltiazem or verapamil. These findings suggest that NO dilates resistance arteries in vivo via direct and/or hyperpolarization-induced closure of CaVS2+-channels and that the increased potency of NO in SH rats may be due to the augmented CaVS2+-channel activity reported in this strain.

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Year:  2005        PMID： 16321377     DOI： 10.1016/j.ejphar.2005.10.056

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

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Journal:  Dokl Biochem Biophys       Date:  2007 Jul-Aug       Impact factor: 0.788

2.  S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.

Authors:  Taiming Liu; Hobe J Schroeder; Meijuan Zhang; Sean M Wilson; Michael H Terry; Lawrence D Longo; Gordon G Power; Arlin B Blood
Journal:  Nitric Oxide       Date:  2016-05-25       Impact factor: 4.427

3.  Local and systemic vasodilatory effects of low molecular weight S-nitrosothiols.

Authors:  Taiming Liu; Hobe J Schroeder; Sean M Wilson; Michael H Terry; Monica Romero; Lawrence D Longo; Gordon G Power; Arlin B Blood
Journal:  Free Radic Biol Med       Date:  2015-12-12       Impact factor: 7.376

4.  Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells.

Authors:  C E Van Hove; C Van der Donckt; A G Herman; H Bult; P Fransen
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Journal:  Hypertens Res       Date:  2021-04-19       Impact factor: 3.872

6.  Nitric oxide signalling augments neuronal voltage-gated L-type (Ca(v)1) and P/q-type (Ca(v)2.1) channels in the mouse medial nucleus of the trapezoid body.

Authors:  Adam J B Tozer; Ian D Forsythe; Joern R Steinert
Journal:  PLoS One       Date:  2012-02-28       Impact factor: 3.240

7.  l-arginine Supplementation Increased Only Endothelium-Dependent Relaxation in Sprague-Dawley Rats Fed a High-Salt Diet by Enhancing Abdominal Aorta Endothelial Nitric Oxide Synthase Gene Expression.

Authors:  Abdullahi Adejare; Ahmed Oloyo; Chikodi Anigbogu; Smith Jaja
Journal:  Clin Med Insights Cardiol       Date:  2020-01-29
  7 in total

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