Literature DB >> 16321036

Reduction of 2,3-dihydroisoxazoles to beta-amino ketones and beta-amino alcohols.

Patrick Aschwanden1, Lisbet Kvaernø, Roger W Geisser, Florian Kleinbeck, Erick M Carreira.   

Abstract

[chemical reaction: see text]. We report the reduction of 2,3-dihydroisoxazoles to beta-amino ketones and beta-amino alcohols. The latter are obtained in high diastereoselectivity with preference for the syn isomer.

Entities:  

Year:  2005        PMID： 16321036     DOI： 10.1021/ol052540c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination.

Authors:  Saki Ichikawa; Stephen L Buchwald
Journal:  Org Lett       Date:  2019-10-18       Impact factor: 6.005

2.  Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction.

Authors:  Salvatore V Giofrè; Santa Cirmi; Raffaella Mancuso; Francesco Nicolò; Giuseppe Lanza; Laura Legnani; Agata Campisi; Maria A Chiacchio; Michele Navarra; Bartolo Gabriele; Roberto Romeo
Journal:  Beilstein J Org Chem       Date:  2016-12-20       Impact factor: 2.883

3.  A modular and divergent approach to spirocyclic pyrrolidines.

Authors:  Benjamin D A Shennan; Peter W Smith; Yusuke Ogura; Darren J Dixon
Journal:  Chem Sci       Date:  2020-08-07       Impact factor: 9.825
  3 in total

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