OBJECTIVE: To identify risk factors for group B streptococcus (GBS) colonization in pregnancy, hypothesizing that health care workers may have increased risk. METHODS: Population-based, case-control study comparing 40,459 cases of GBS colonization, identified from Washington State birth certificate data linked to hospital discharge data for live births between 1997 and 2002, with 84,268 controls matched by year of delivery by multivariable logistic regression. RESULTS: After adjustment for confounders, the following characteristics were independently associated with increased maternal GBS colonization: health care occupation (odds ratio [OR] 1.22, 95% confidence interval [CI] 1.07-1.38), black race (OR 1.54, 95% CI 1.36-1.74), overweight (OR 1.07, 95% CI 1.01-1.12), obesity (OR 1.20, 95% CI 1.13-1.28), severe obesity (OR 1.45, 95% CI 1.28-1.63), median income greater than lowest quintile (OR 1.29, 95% CI 1.20-1.39 for fifth versus first quintile), some high school education (OR 1.21, 95% CI 1.05-1.40), high school graduate (OR 1.35, 95% CI 1.16-1.56), and adequate prenatal care (OR 1.14, 95% CI 1.06-1.24). Hispanic women (OR 0.88, 95% CI 0.80-0.96) and smokers (OR for 1-10 cigarettes per day 0.90, 95% CI 0.83-0.97) had a decreased odds of colonization. CONCLUSION: Health care workers, black women, and women with high body mass index may be at greater risk of GBS colonization in pregnancy. However, any increases in risk are modest and the association between a health care occupation and GBS colonization needs to be investigated further.
OBJECTIVE: To identify risk factors for group B streptococcus (GBS) colonization in pregnancy, hypothesizing that health care workers may have increased risk. METHODS: Population-based, case-control study comparing 40,459 cases of GBS colonization, identified from Washington State birth certificate data linked to hospital discharge data for live births between 1997 and 2002, with 84,268 controls matched by year of delivery by multivariable logistic regression. RESULTS: After adjustment for confounders, the following characteristics were independently associated with increased maternal GBS colonization: health care occupation (odds ratio [OR] 1.22, 95% confidence interval [CI] 1.07-1.38), black race (OR 1.54, 95% CI 1.36-1.74), overweight (OR 1.07, 95% CI 1.01-1.12), obesity (OR 1.20, 95% CI 1.13-1.28), severe obesity (OR 1.45, 95% CI 1.28-1.63), median income greater than lowest quintile (OR 1.29, 95% CI 1.20-1.39 for fifth versus first quintile), some high school education (OR 1.21, 95% CI 1.05-1.40), high school graduate (OR 1.35, 95% CI 1.16-1.56), and adequate prenatal care (OR 1.14, 95% CI 1.06-1.24). Hispanic women (OR 0.88, 95% CI 0.80-0.96) and smokers (OR for 1-10 cigarettes per day 0.90, 95% CI 0.83-0.97) had a decreased odds of colonization. CONCLUSION: Health care workers, black women, and women with high body mass index may be at greater risk of GBS colonization in pregnancy. However, any increases in risk are modest and the association between a health care occupation and GBS colonization needs to be investigated further.
Authors: Kartik K Venkatesh; Catherine J Vladutiu; Robert A Strauss; John M Thorp; Jeffrey S A Stringer; David M Stamilio; Brenna L Hughes; Sarah Dotters-Katz Journal: J Womens Health (Larchmt) Date: 2020-05-04 Impact factor: 2.681
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Authors: Anna C Seale; Angela C Koech; Anna E Sheppard; Hellen C Barsosio; Joyce Langat; Emily Anyango; Stella Mwakio; Salim Mwarumba; Susan C Morpeth; Kirimi Anampiu; Alison Vaughan; Adam Giess; Polycarp Mogeni; Leahbell Walusuna; Hope Mwangudzah; Doris Mwanzui; Mariam Salim; Bryn Kemp; Caroline Jones; Neema Mturi; Benjamin Tsofa; Edward Mumbo; David Mulewa; Victor Bandika; Musimbi Soita; Maureen Owiti; Norris Onzere; A Sarah Walker; Stephanie J Schrag; Stephen H Kennedy; Greg Fegan; Derrick W Crook; James A Berkley Journal: Nat Microbiol Date: 2016-05-23 Impact factor: 17.745