Literature DB >> 16318911

In vitro activity of lauric acid or myristylamine in combination with six antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA).

Takashi Kitahara1, Yuko Aoyama, Yoichi Hirakata, Shimeru Kamihira, Shigeru Kohno, Nobuhiro Ichikawa, Mikiro Nakashima, Hitoshi Sasaki, Shun Higuchi.   

Abstract

The objective of this study was to investigate the in vitro activities of lauric acid and myristylamine in combination with six antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA). The combination effect of lipids and antimicrobial agents was evaluated by the checkerboard method to obtain a fractional inhibitory concentration (FIC) index. The effects of lauric acid + gentamicin (GM) and lauric acid + imipenem (IPM) combinations were synergistic against the clinical isolates in 12 combinations. An antagonistic FIC index was observed only with the myristylamine + GM combination. We investigated in detail the antimicrobial activity for two combinations that showed a synergistic effect. The cytotoxicity of lauric acid was not enhanced by the addition of GM and IPM. In time-kill studies, lauric acid + GM and lauric acid + IPM combinations at one-eighth of the minimum inhibitory concentration produced a bacteriostatic effect.

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Year:  2005        PMID： 16318911     DOI： 10.1016/j.ijantimicag.2005.08.020

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  4 in total

1.  In vitro antagonistic inhibitory effects of palm seed crude oils and their main constituent, lauric acid, with oxacillin in Staphylococcus aureus.

Authors:  Klara Lalouckova; Eva Skrivanova; Johana Rondevaldova; Adela Frankova; Josef Soukup; Ladislav Kokoska
Journal:  Sci Rep       Date:  2021-01-08       Impact factor: 4.379

2.  Improvement of medium chain fatty acid content and antimicrobial activity of coconut oil via solid-state fermentation using a Malaysian Geotrichum candidum.

Authors:  Anahita Khoramnia; Afshin Ebrahimpour; Raheleh Ghanbari; Zahra Ajdari; Oi-Ming Lai
Journal:  Biomed Res Int       Date:  2013-07-18       Impact factor: 3.411

3.  Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus.

Authors:  Andrew P Desbois; Keelan C Lawlor
Journal:  Mar Drugs       Date:  2013-11-13       Impact factor: 5.118

4.  Lauric Acid Is an Inhibitor of Clostridium difficile Growth in Vitro and Reduces Inflammation in a Mouse Infection Model.

Authors:  Hsiao-Ting Yang; Jenn-Wei Chen; Jagat Rathod; Yu-Zhen Jiang; Pei-Jane Tsai; Yuan-Pin Hung; Wen-Chien Ko; Daniel Paredes-Sabja; I-Hsiu Huang
Journal:  Front Microbiol       Date:  2018-01-17       Impact factor: 5.640
  4 in total

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