Literature DB >> 16315223

Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model.

Stephen R Carino1, David C Sperry, Michael Hawley.   

Abstract

The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed.

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Year:  2006        PMID： 16315223     DOI： 10.1002/jps.20495

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  15 in total

1.  Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug.

Authors:  Ajit S Narang; Sherif Badawy; Qingmei Ye; Dhaval Patel; Maria Vincent; Krishnaswamy Raghavan; Yande Huang; Aaron Yamniuk; Balvinder Vig; John Crison; George Derbin; Yan Xu; Antonio Ramirez; Michael Galella; Frank A Rinaldi
Journal:  Pharm Res       Date:  2015-02-28       Impact factor: 4.200

2.  Assessment of In Vivo Clinical Product Performance of a Weak Basic Drug by Integration of In Vitro Dissolution Tests and Physiologically Based Absorption Modeling.

Authors:  Xuan Ding; Ivelina Gueorguieva; James A Wesley; Lee J Burns; Carrie A Coutant
Journal:  AAPS J       Date:  2015-07-01       Impact factor: 4.009

3.  The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration.

Authors:  Alexandros Kourentas; Maria Vertzoni; Vicky Barmpatsalou; Patrick Augustijns; Stefania Beato; James Butler; Rene Holm; Neils Ouwerkerk; Joerg Rosenberg; Tomokazu Tajiri; Christer Tannergren; Mira Symillides; Christos Reppas
Journal:  AAPS J       Date:  2018-05-24       Impact factor: 4.009

Review 4.  Characterization of supersaturatable formulations for improved absorption of poorly soluble drugs.

Authors:  Ping Gao; Yi Shi
Journal:  AAPS J       Date:  2012-07-14       Impact factor: 4.009

5.  Improving Dissolution Rate of Carbamazepine-Glutaric Acid Cocrystal Through Solubilization by Excess Coformer.

Authors:  Hiroyuki Yamashita; Changquan Calvin Sun
Journal:  Pharm Res       Date:  2017-12-29       Impact factor: 4.200

6.  The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC.

Authors:  Yasuhiro Tsume; Deanna M Mudie; Peter Langguth; Greg E Amidon; Gordon L Amidon
Journal:  Eur J Pharm Sci       Date:  2014-01-28       Impact factor: 4.384

Review 7.  Physiological parameters for oral delivery and in vitro testing.

Authors:  Deanna M Mudie; Gordon L Amidon; Gregory E Amidon
Journal:  Mol Pharm       Date:  2010-09-07       Impact factor: 4.939

8.  Predicting intestinal precipitation--a case example for a basic BCS class II drug.

Authors:  Sara Carlert; Anna Pålsson; Gunilla Hanisch; Christian von Corswant; Catarina Nilsson; Lennart Lindfors; Hans Lennernäs; Bertil Abrahamsson
Journal:  Pharm Res       Date:  2010-08-18       Impact factor: 4.200

Review 9.  Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project.

Authors:  Bart Hens; Patrick D Sinko; Nicholas Job; Meagan Dean; Jozef Al-Gousous; Niloufar Salehi; Robert M Ziff; Yasuhiro Tsume; Marival Bermejo; Paulo Paixão; James G Brasseur; Alex Yu; Arjang Talattof; Gail Benninghoff; Peter Langguth; Hans Lennernäs; William L Hasler; Luca Marciani; Joseph Dickens; Kerby Shedden; Duxin Sun; Gregory E Amidon; Gordon L Amidon
Journal:  Int J Pharm       Date:  2018-06-23       Impact factor: 5.875

10.  Evaluation of Carbamazepine (CBZ) Supersaturatable Self-Microemulsifying (S-SMEDDS) Formulation In-vitro and In-vivo.

Authors:  Zhang Nan; Gao Lijun; Wang Tao; Quan Dongqin
Journal:  Iran J Pharm Res       Date:  2012       Impact factor: 1.696
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