Literature DB >> 16314581

Seeing is believing: structure of the catalytic domain of HIV-1 integrase in complex with human LEDGF/p75.

Christina Marchetti Bradley1, Robert Craigie.   

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Year:  2005        PMID： 16314581      PMCID： PMC1308931          DOI： 10.1073/pnas.0509078102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  21 in total

Review 1.  Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways.

Authors:  S P Goff
Journal:  J Gene Med       Date:  2001 Nov-Dec       Impact factor: 4.565

2.  HIV-1 integration in the human genome favors active genes and local hotspots.

Authors:  Astrid R W Schröder; Paul Shinn; Huaming Chen; Charles Berry; Joseph R Ecker; Frederic Bushman
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

3.  Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.

Authors:  Stéphane Emiliani; Aurélie Mousnier; Katrien Busschots; Marlène Maroun; Bénédicte Van Maele; Denis Tempé; Linos Vandekerckhove; Fanny Moisant; Lilia Ben-Slama; Myriam Witvrouw; Frauke Christ; Jean-Christophe Rain; Catherine Dargemont; Zeger Debyser; Richard Benarous
Journal:  J Biol Chem       Date:  2005-04-25       Impact factor: 5.157

4.  HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.

Authors:  Peter Cherepanov; Goedele Maertens; Paul Proost; Bart Devreese; Jozef Van Beeumen; Yves Engelborghs; Erik De Clercq; Zeger Debyser
Journal:  J Biol Chem       Date:  2002-10-28       Impact factor: 5.157

5.  Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells.

Authors:  Stephanie Laufs; Bernhard Gentner; K Zsuzsanna Nagy; Anna Jauch; Axel Benner; Sonja Naundorf; Klaus Kuehlcke; Bernhard Schiedlmeier; Anthony D Ho; W Jens Zeller; Stefan Fruehauf
Journal:  Blood       Date:  2002-11-07       Impact factor: 22.113

6.  Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

Authors:  Peter Cherepanov; Andre L B Ambrosio; Shaila Rahman; Tom Ellenberger; Alan Engelman
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-31       Impact factor: 11.205

7.  Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.

Authors:  Daria J Hazuda; Steven D Young; James P Guare; Neville J Anthony; Robert P Gomez; John S Wai; Joseph P Vacca; Larry Handt; Sherri L Motzel; Hilton J Klein; Geethanjali Dornadula; Robert M Danovich; Marc V Witmer; Keith A A Wilson; Lynda Tussey; William A Schleif; Lori S Gabryelski; Lixia Jin; Michael D Miller; Danilo R Casimiro; Emilio A Emini; John W Shiver
Journal:  Science       Date:  2004-07-08       Impact factor: 47.728

8.  LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

Authors:  Goedele Maertens; Peter Cherepanov; Wim Pluymers; Katrien Busschots; Erik De Clercq; Zeger Debyser; Yves Engelborghs
Journal:  J Biol Chem       Date:  2003-06-09       Impact factor: 5.157

9.  Transcription start regions in the human genome are favored targets for MLV integration.

Authors:  Xiaolin Wu; Yuan Li; Bruce Crise; Shawn M Burgess
Journal:  Science       Date:  2003-06-13       Impact factor: 47.728

10.  Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.

Authors:  Goedele Maertens; Peter Cherepanov; Zeger Debyser; Yves Engelborghs; Alan Engelman
Journal:  J Biol Chem       Date:  2004-05-25       Impact factor: 5.157
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  3 in total

1.  Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited.

Authors:  Jing Tang; Kasthuraiah Maddali; Yves Pommier; Yuk Y Sham; Zhengqiang Wang
Journal:  Bioorg Med Chem Lett       Date:  2010-04-21       Impact factor: 2.823

Review 2.  Integrase, LEDGF/p75 and HIV replication.

Authors:  E M Poeschla
Journal:  Cell Mol Life Sci       Date:  2008-05       Impact factor: 9.261

3.  A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.

Authors:  Fanny Turlure; Goedele Maertens; Shaila Rahman; Peter Cherepanov; Alan Engelman
Journal:  Nucleic Acids Res       Date:  2006-03-20       Impact factor: 16.971
  3 in total

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