BACKGROUND: Depression leads to adverse outcomes in patients with coronary heart disease (CHD). Medication nonadherence is a potential mechanism for the increased risk of CHD events associated with depression, but it is not known whether depression is associated with medication nonadherence in outpatients with stable CHD. METHODS: We examined the association between current major depression (assessed using the Diagnostic Interview Schedule) and self-reported medication adherence in a cross-sectional study of 940 outpatients with stable CHD. RESULTS: A total of 204 participants (22%) had major depression. Twenty-eight (14%) of 204 depressed participants reported not taking their medications as prescribed compared with 40 (5%) of 736 nondepressed participants (odds ratio [OR], 2.8; 95% confidence interval [CI], 1.7-4.7; P<.001). Twice as many depressed participants as nondepressed participants (18% vs 9%) reported forgetting to take their medications (OR, 2.4; 95% CI, 1.6-3.8; P<.001). Nine percent of depressed participants and 4% of nondepressed participants reported deciding to skip their medications (OR, 2.2; 95% CI, 1.2-4.2; P = .01). The relationship between depression and nonadherence persisted after adjustment for potential confounding variables, including age, ethnicity, education, social support, and measures of cardiac disease severity (OR, 2.2; 95% CI, 1.2-3.9; P = .009 for not taking medications as prescribed). CONCLUSIONS: Depression is associated with medication nonadherence in outpatients with CHD. Medication nonadherence may contribute to adverse cardiovascular outcomes in depressed patients.
BACKGROUND:Depression leads to adverse outcomes in patients with coronary heart disease (CHD). Medication nonadherence is a potential mechanism for the increased risk of CHD events associated with depression, but it is not known whether depression is associated with medication nonadherence in outpatients with stable CHD. METHODS: We examined the association between current major depression (assessed using the Diagnostic Interview Schedule) and self-reported medication adherence in a cross-sectional study of 940 outpatients with stable CHD. RESULTS: A total of 204 participants (22%) had major depression. Twenty-eight (14%) of 204 depressedparticipants reported not taking their medications as prescribed compared with 40 (5%) of 736 nondepressed participants (odds ratio [OR], 2.8; 95% confidence interval [CI], 1.7-4.7; P<.001). Twice as many depressedparticipants as nondepressed participants (18% vs 9%) reported forgetting to take their medications (OR, 2.4; 95% CI, 1.6-3.8; P<.001). Nine percent of depressedparticipants and 4% of nondepressed participants reported deciding to skip their medications (OR, 2.2; 95% CI, 1.2-4.2; P = .01). The relationship between depression and nonadherence persisted after adjustment for potential confounding variables, including age, ethnicity, education, social support, and measures of cardiac disease severity (OR, 2.2; 95% CI, 1.2-3.9; P = .009 for not taking medications as prescribed). CONCLUSIONS:Depression is associated with medication nonadherence in outpatients with CHD. Medication nonadherence may contribute to adverse cardiovascular outcomes in depressedpatients.
Authors: Elizabeth H B Lin; Wayne Katon; Michael Von Korff; Carolyn Rutter; Greg E Simon; Malia Oliver; Paul Ciechanowski; Evette J Ludman; Terry Bush; Bessie Young Journal: Diabetes Care Date: 2004-09 Impact factor: 19.112
Authors: Christian Otte; Charles R Marmar; Sharon S Pipkin; Rudolf Moos; Warren S Browner; Mary A Whooley Journal: Biol Psychiatry Date: 2004-08-15 Impact factor: 13.382
Authors: Robert M Carney; James A Blumenthal; Diane Catellier; Kenneth E Freedland; Lisa F Berkman; Lana L Watkins; Susan M Czajkowski; Junichiro Hayano; Allan S Jaffe Journal: Am J Cardiol Date: 2003-12-01 Impact factor: 2.778
Authors: Salim Yusuf; Steven Hawken; Stephanie Ounpuu; Tony Dans; Alvaro Avezum; Fernando Lanas; Matthew McQueen; Andrzej Budaj; Prem Pais; John Varigos; Liu Lisheng Journal: Lancet Date: 2004 Sep 11-17 Impact factor: 79.321
Authors: Wayne Katon; Michael von Korff; Paul Ciechanowski; Joan Russo; Elizabeth Lin; Gregory Simon; Evette Ludman; Edward Walker; Terry Bush; Bessie Young Journal: Diabetes Care Date: 2004-04 Impact factor: 19.112
Authors: Carolyn Payne; E C Hedberg; Michael Kozloski; William Dale; Martha K McClintock Journal: J Gerontol B Psychol Sci Soc Sci Date: 2014-11 Impact factor: 4.077
Authors: Carol M Greco; Tracy Li; Abdus Sattar; Amy H Kao; Natalya Danchenko; Daniel Edmundowicz; Kim Sutton-Tyrrell; Russell P Tracy; Lewis H Kuller; Susan Manzi Journal: J Rheumatol Date: 2011-12-15 Impact factor: 4.666
Authors: Emily C Gathright; Mary A Dolansky; John Gunstad; Joseph D Redle; Richard A Josephson; Shirley M Moore; Joel W Hughes Journal: Health Psychol Date: 2017-07-20 Impact factor: 4.267