BACKGROUND: Growing evidence indicates that the administration of large amounts of ghrelin to humans increases circulating concentrations of several pituitary and adrenal hormones, induces hyperglycemia and reduces serum insulin concentrations. At present, it is not known whether physiological increments in plasma ghrelin concentrations affect glucose kinetics or hormone concentrations in humans. METHODS AND RESULTS: We compared the effects of two- and three-fold increments in plasma ghrelin concentrations in eight healthy subjects during a 2 h intravenous infusion of 7.5 (GHRE7.5), 15 (GHRE15) pmol kg(-1) min(-1) acylated human ghrelin or placebo (PL), in a randomized double-blind study. Compared with PL (146 +/- 24 pM) plasma ghrelin concentrations increased at 120 min (p<0.001) about two-fold after GHRE7.5 (300 +/- 35 pM) and three-fold after GHRE15 (494 +/- 30 pM). GHRE15 significantly increased circulating concentrations of NEFA, GH, ACTH, epinephrine, and prolactin (p<0.01). GHRELIN7.5 significantly (p<0.01) increased only serum GH concentrations. Neither ghrelin infusions changed glucose flux or circulating concentrations of glucose, insulin, C-peptide, glucagon, IGF-1, cortisol and norepinephrine. CONCLUSIONS: GH secretion is the only response that is stimulated by physiological increments in plasma ghrelin concentrations; about three-fold increases in plasma ghrelin concentrations are required to elicit the responses of epinephrine, prolactin, ACTH and NEFA.
RCT Entities:
BACKGROUND: Growing evidence indicates that the administration of large amounts of ghrelin to humans increases circulating concentrations of several pituitary and adrenal hormones, induces hyperglycemia and reduces serum insulin concentrations. At present, it is not known whether physiological increments in plasma ghrelin concentrations affect glucose kinetics or hormone concentrations in humans. METHODS AND RESULTS: We compared the effects of two- and three-fold increments in plasma ghrelin concentrations in eight healthy subjects during a 2 h intravenous infusion of 7.5 (GHRE7.5), 15 (GHRE15) pmol kg(-1) min(-1) acylated humanghrelin or placebo (PL), in a randomized double-blind study. Compared with PL (146 +/- 24 pM) plasma ghrelin concentrations increased at 120 min (p<0.001) about two-fold after GHRE7.5 (300 +/- 35 pM) and three-fold after GHRE15 (494 +/- 30 pM). GHRE15 significantly increased circulating concentrations of NEFA, GH, ACTH, epinephrine, and prolactin (p<0.01). GHRELIN7.5 significantly (p<0.01) increased only serum GH concentrations. Neither ghrelin infusions changed glucose flux or circulating concentrations of glucose, insulin, C-peptide, glucagon, IGF-1, cortisol and norepinephrine. CONCLUSIONS: GH secretion is the only response that is stimulated by physiological increments in plasma ghrelin concentrations; about three-fold increases in plasma ghrelin concentrations are required to elicit the responses of epinephrine, prolactin, ACTH and NEFA.
Authors: Robyn A Tamboli; Joseph Antoun; Reem M Sidani; Austin Clements; Emily E Harmata; Pam Marks-Shulman; Bruce D Gaylinn; Brandon Williams; Ronald H Clements; Vance L Albaugh; Naji N Abumrad Journal: Diabetes Obes Metab Date: 2017-05-31 Impact factor: 6.577
Authors: William S Denney; Gabriele E Sonnenberg; Santos Carvajal-Gonzalez; Theresa Tuthill; V Margaret Jackson Journal: Br J Clin Pharmacol Date: 2016-10-29 Impact factor: 4.335
Authors: J Kong; J Chuddy; I A Stock; P M Loria; S V Straub; C Vage; K O Cameron; S K Bhattacharya; K Lapham; K F McClure; Y Zhang; V M Jackson Journal: Br J Pharmacol Date: 2016-03-17 Impact factor: 8.739
Authors: Samit K Bhattacharya; Kim Andrews; Ramsay Beveridge; Kimberly O Cameron; Chiliu Chen; Matthew Dunn; Dilinie Fernando; Hua Gao; David Hepworth; V Margaret Jackson; Vishal Khot; Jimmy Kong; Rachel E Kosa; Kimberly Lapham; Paula M Loria; Allyn T Londregan; Kim F McClure; Suvi T M Orr; Jigna Patel; Colin Rose; James Saenz; Ingrid A Stock; Gregory Storer; Maria VanVolkenburg; Derek Vrieze; Guoqiang Wang; Jun Xiao; Yingxin Zhang Journal: ACS Med Chem Lett Date: 2014-02-24 Impact factor: 4.345
Authors: Jenny Tong; Ronald L Prigeon; Harold W Davis; Martin Bidlingmaier; Steven E Kahn; David E Cummings; Matthias H Tschöp; David D'Alessio Journal: Diabetes Date: 2010-06-28 Impact factor: 9.461
Authors: A Benso; E Gramaglia; I Olivetti; M Tomelini; S Belcastro; E Calvi; A Dotta; D St-Pierre; E Ghigo; F Broglio Journal: Endocrine Date: 2014-07-11 Impact factor: 3.633