BACKGROUND: Tuberculosis is a chronic disease caused mainly by Mycobacterium tuberculosis. The emergence of antibiotic-resistant strains of this species underscores the need for novel effective drugs against resistant mycobacteria as first-line antituberculosis medications. METHODS: Crude aqueous (obtained by decoction, in accordance with the traditional mode of preparation), methanol, acetone, and hexane extracts from aerial parts of Artemisia ludoviciana Nutt., Chenopodium ambrosioides L., Marrubium vulgare L., Mentha spicata L., and Flourensia cernua DC were assessed for their ability to either inhibit the growth of or kill M. tuberculosis strains H37Rv and CIBIN:UMF:15:99, the former being sensitive to, and the latter resistant to, streptomycin, isoniazide, rifampin, ethambutol, and pyrazinamide. These five plant species are used in Mexico to treat respiratory disorders. RESULTS: Flourensia cernua was the uniquely active plant among those evaluated. Its hexane and acetone extracts not only inhibited the growth of but killed M. tuberculosis. The hexane extract showed a minimal inhibitory concentration (MIC) of 50 and 25 microg/mL against sensitive and resistant strains, respectively; the acetone extract was active against only CIBIN:UMF:15:99 (MIC = 100 microg/mL). CONCLUSIONS: The hexane extract from F. cernua leaves could be an important source of bactericidal compounds against multidrug-resistant M. tuberculosis.
BACKGROUND:Tuberculosis is a chronic disease caused mainly by Mycobacterium tuberculosis. The emergence of antibiotic-resistant strains of this species underscores the need for novel effective drugs against resistant mycobacteria as first-line antituberculosis medications. METHODS: Crude aqueous (obtained by decoction, in accordance with the traditional mode of preparation), methanol, acetone, and hexane extracts from aerial parts of Artemisia ludoviciana Nutt., Chenopodium ambrosioides L., Marrubium vulgare L., Mentha spicata L., and Flourensia cernua DC were assessed for their ability to either inhibit the growth of or kill M. tuberculosis strains H37Rv and CIBIN:UMF:15:99, the former being sensitive to, and the latter resistant to, streptomycin, isoniazide, rifampin, ethambutol, and pyrazinamide. These five plant species are used in Mexico to treat respiratory disorders. RESULTS: Flourensia cernua was the uniquely active plant among those evaluated. Its hexane and acetone extracts not only inhibited the growth of but killed M. tuberculosis. The hexane extract showed a minimal inhibitory concentration (MIC) of 50 and 25 microg/mL against sensitive and resistant strains, respectively; the acetone extract was active against only CIBIN:UMF:15:99 (MIC = 100 microg/mL). CONCLUSIONS: The hexane extract from F. cernua leaves could be an important source of bactericidal compounds against multidrug-resistant M. tuberculosis.
Authors: Gloria M Molina-Salinas; Verónica M Rivas-Galindo; Salvador Said-Fernández; David C Lankin; Marcelo A Muñoz; Pedro Joseph-Nathan; Guido F Pauli; Noemí Waksman Journal: J Nat Prod Date: 2011-08-22 Impact factor: 4.050
Authors: K Peñuelas-Urquides; L González-Escalante; L Villarreal-Treviño; B Silva-Ramírez; D J Gutiérrez-Fuentes; R Mojica-Espinosa; C Rangel-Escareño; L Uribe-Figueroa; G M Molina-Salinas; J Dávila-Velderrain; F Castorena-Torres; M Bermúdez de León; S Said-Fernández Journal: Curr Microbiol Date: 2013-05-07 Impact factor: 2.188
Authors: Marcela Gamboa-Angulo; Gloria M Molina-Salinas; Manuel Chan-Bacab; Sergio R Peraza-Sánchez; Gabriela Heredia; Susana C de la Rosa-García; Manuela Reyes-Estebanez Journal: Parasitol Res Date: 2012-10-21 Impact factor: 2.289
Authors: Ezekiel Green; Lawrence C Obi; Amidou Samie; Pascal O Bessong; Roland N Ndip Journal: BMC Complement Altern Med Date: 2011-04-11 Impact factor: 3.659
Authors: Gloria María Molina-Salinas; Luis Manuel Peña-Rodríguez; Benito David Mata-Cárdenas; Fabiola Escalante-Erosa; Silvia González-Hernández; Víctor Manuel Torres de la Cruz; Herminia Guadalupe Martínez-Rodríguez; Salvador Said-Fernández Journal: Evid Based Complement Alternat Med Date: 2011-03-31 Impact factor: 2.629
Authors: Adelina Jiménez-Arellanes; Jorge Cornejo-Garrido; Gabriela Rojas-Bribiesca; María Del Pilar Nicasio-Torres; Salvador Said-Fernández; Benito David Mata-Cárdenas; Gloria María Molina-Salinas; Jaime Tortoriello; Mariana Meckes-Fischer Journal: Evid Based Complement Alternat Med Date: 2012-08-26 Impact factor: 2.629