| Literature DB >> 16314096 |
Qing Yang1, Jianqiang Xu, Yuanshe Sun, Zhigang Li, Yonggang Li, Xuhong Qian.
Abstract
A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.Entities:
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Year: 2005 PMID： 16314096 DOI： 10.1016/j.bmcl.2005.11.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823