Immune reconstitution syndrome associated with parvovirus B19-induced pure red cell aplasia during highly active antiretroviral therapy.

Persistent parvovirus B19 (B19) manifested as chronic pure red cell aplasia (PRCA) has been described in HIV patients. Immune reconstitution syndrome (IRS) is an immune response to an occult opportunistic pathogen or tumor antigen, usually occurs after antiretroviral treatment. We describe the first case of IRS associated with B19-induced PRCA during highly active antiretroviral therapy.