| Literature DB >> 16313906 |
Tianhong Pan1, Xinqun Li, Wenjie Xie, Joseph Jankovic, Weidong Le.
Abstract
Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.Entities:
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Year: 2005 PMID： 16313906 DOI： 10.1016/j.febslet.2005.10.067
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124