T A Mills1, M Wareing, G J Bugg, S L Greenwood, P N Baker. 1. Maternal & Fetal Health Research Centre, St Mary's Hospital for Women and Children, Division of Human Development, University of Manchester, Manchester, UK.
Abstract
BACKGROUND: In fetal growth restriction (FGR) abnormal umbilical artery (UA) Doppler waveform indices suggest increased vascular resistance and impaired placental blood flow. This study aimed to determine whether UA Doppler waveform indices were related to the vasoreactivity of placental chorionic plate small arteries in normal and FGR pregnancies. MATERIALS AND METHODS: UA Doppler waveform analysis was performed 24 h before delivery in 23 normal term and 15 FGR pregnancies. Post-delivery responses of chorionic plate arteries to vasoactive agents were examined using the technique of wire myography. RESULTS: Altered vascular reactivity to agonists was demonstrated in chorionic plate arteries in FGR pregnancy. Constriction to U46619 (thromboxane mimetic) and relaxation to sodium nitroprusside (nitric oxide donor) were significantly increased in the arteries of FGR pregnancies compared with normal pregnancies. No relationship existed between Doppler indices and chorionic plate responses in normal or FGR pregnancies. CONCLUSIONS: Fetoplacental vascular reactivity is altered in FGR pregnancy independently of UA Doppler waveform indices. Altered function may be additive to the pathophysiology underlying abnormal Doppler waveforms and could contribute to the inappropriate control of vascular tone in FGR.
BACKGROUND: In fetal growth restriction (FGR) abnormal umbilical artery (UA) Doppler waveform indices suggest increased vascular resistance and impaired placental blood flow. This study aimed to determine whether UA Doppler waveform indices were related to the vasoreactivity of placental chorionic plate small arteries in normal and FGR pregnancies. MATERIALS AND METHODS: UA Doppler waveform analysis was performed 24 h before delivery in 23 normal term and 15 FGR pregnancies. Post-delivery responses of chorionic plate arteries to vasoactive agents were examined using the technique of wire myography. RESULTS: Altered vascular reactivity to agonists was demonstrated in chorionic plate arteries in FGR pregnancy. Constriction to U46619 (thromboxane mimetic) and relaxation to sodium nitroprusside (nitric oxidedonor) were significantly increased in the arteries of FGR pregnancies compared with normal pregnancies. No relationship existed between Doppler indices and chorionic plate responses in normal or FGR pregnancies. CONCLUSIONS: Fetoplacental vascular reactivity is altered in FGR pregnancy independently of UA Doppler waveform indices. Altered function may be additive to the pathophysiology underlying abnormal Doppler waveforms and could contribute to the inappropriate control of vascular tone in FGR.
Authors: Lucy E Higgins; Nicolas Rey de Castro; Naa Addo; Mark Wareing; Susan L Greenwood; Rebecca L Jones; Colin P Sibley; Edward D Johnstone; Alexander E P Heazell Journal: PLoS One Date: 2015-06-29 Impact factor: 3.240
Authors: Lewis J Renshall; Mark R Dilworth; Susan L Greenwood; Colin P Sibley; Mark Wareing Journal: Am J Physiol Regul Integr Comp Physiol Date: 2014-07-23 Impact factor: 3.619
Authors: Natalie Cureton; Iana Korotkova; Bernadette Baker; Susan Greenwood; Mark Wareing; Venkata R Kotamraju; Tambet Teesalu; Francesco Cellesi; Nicola Tirelli; Erkki Ruoslahti; John D Aplin; Lynda K Harris Journal: Theranostics Date: 2017-08-29 Impact factor: 11.556