BACKGROUND: Brachial blood pressure predicts cardiovascular outcome at rest and during exercise. However, because of pulse pressure amplification, there is a marked difference between brachial pressure and central (aortic) pressure. Although central pressure is likely to have greater clinical importance, very little data exist regarding the central haemodynamic response to exercise. The aim of the present study was to determine the central and peripheral haemodynamic response to incremental aerobic exercise. MATERIALS AND METHODS: Twelve healthy men aged 31 +/- 1 years (mean +/- SEM) exercised at 50%, 60%, 70% and 80% of their maximal heart rate (HRmax) on a bicycle ergometer. Central blood pressure and estimated aortic pulse wave velocity, assessed by timing of the reflected wave (T(R)), were obtained noninvasively using pulse wave analysis. Pulse pressure amplification was defined as the ratio of peripheral to central pulse pressure and, to assess the influence of wave reflection on amplification, the ratio of peripheral pulse pressure to nonaugmented central pulse pressure (PPP : CDBP-P1) was also calculated. RESULTS: During exercise, there was a significant, intensity-related, increase in mean arterial pressure and heart rate (P < 0.001). There was also a significant increase in pulse pressure amplification and in PPP : CDBP-P(1) (P < 0.001), but both were independent of exercise intensity. Estimated aortic pulse wave velocity increased during exercise (P < 0.001), indicating increased aortic stiffness. There was also a positive association between aortic pulse wave velocity and mean arterial pressure (r = 0.54; P < 0.001). CONCLUSIONS: Exercise significantly increases pulse pressure amplification and estimated aortic stiffness.
BACKGROUND: Brachial blood pressure predicts cardiovascular outcome at rest and during exercise. However, because of pulse pressure amplification, there is a marked difference between brachial pressure and central (aortic) pressure. Although central pressure is likely to have greater clinical importance, very little data exist regarding the central haemodynamic response to exercise. The aim of the present study was to determine the central and peripheral haemodynamic response to incremental aerobic exercise. MATERIALS AND METHODS: Twelve healthy men aged 31 +/- 1 years (mean +/- SEM) exercised at 50%, 60%, 70% and 80% of their maximal heart rate (HRmax) on a bicycle ergometer. Central blood pressure and estimated aortic pulse wave velocity, assessed by timing of the reflected wave (T(R)), were obtained noninvasively using pulse wave analysis. Pulse pressure amplification was defined as the ratio of peripheral to central pulse pressure and, to assess the influence of wave reflection on amplification, the ratio of peripheral pulse pressure to nonaugmented central pulse pressure (PPP : CDBP-P1) was also calculated. RESULTS: During exercise, there was a significant, intensity-related, increase in mean arterial pressure and heart rate (P < 0.001). There was also a significant increase in pulse pressure amplification and in PPP : CDBP-P(1) (P < 0.001), but both were independent of exercise intensity. Estimated aortic pulse wave velocity increased during exercise (P < 0.001), indicating increased aortic stiffness. There was also a positive association between aortic pulse wave velocity and mean arterial pressure (r = 0.54; P < 0.001). CONCLUSIONS: Exercise significantly increases pulse pressure amplification and estimated aortic stiffness.
Authors: Paul D Chantler; Vojtech Melenovsky; Steven P Schulman; Gary Gerstenblith; Lewis C Becker; Luigi Ferrucci; Jerome L Fleg; Edward G Lakatta; Samer S Najjar Journal: Am J Physiol Heart Circ Physiol Date: 2011-10-14 Impact factor: 4.733
Authors: N E Moyen; M S Ganio; J M Burchfield; M A Tucker; M A Gonzalez; E K Dougherty; F B Robinson; C B Ridings; J C Veilleux Journal: Int J Biometeorol Date: 2015-08-13 Impact factor: 3.787
Authors: Andrew F Mutter; Alexandra B Cooke; Olivier Saleh; Yessica-Haydee Gomez; Stella S Daskalopoulou Journal: Hypertens Res Date: 2016-10-13 Impact factor: 3.872
Authors: Eric J Stöhr; Barry McDonnell; Jane Thompson; Keeron Stone; Tom Bull; Rory Houston; John Cockcroft; Rob Shave Journal: J Physiol Date: 2012-03-19 Impact factor: 5.182
Authors: Lindy Rossow; Christopher A Fahs; Myriam Guerra; Sae Young Jae; Kevin S Heffernan; Bo Fernhall Journal: Eur J Appl Physiol Date: 2010-06-30 Impact factor: 3.078
Authors: Hima Vedam; Craig L Phillips; David Wang; David J Barnes; Jan A Hedner; Gunnar Unger; Ronald R Grunstein Journal: Eur J Appl Physiol Date: 2008-09-25 Impact factor: 3.078