BACKGROUND: Breast cancer treatments are most effective when initiated early, with very poor efficacy against metastatic disease. In seeking a readily metastasizing mouse breast cancer model to facilitate the search for effective therapies, E0771 medullary adenocarcinomas implanted subcutaneously in syngeneic C57BL/6 mice were studied. MATERIALS AND METHODS: Standard pathological, histological and immunological methodologies were used. RESULTS: The aggressive estrogen receptor-positive tumor invaded locally into the peritoneal cavity in 56% of mice, as well as metastasizing to the lungs in 52% of mice. The metastasis was a spontaneous event and immunosuppression was seen (e.g. generation of lyphokine activated killer cells and allogeneic cytotoxic T lymphocytes cytolytic activities ex vivo were suppressed). Other pathological events noted as the tumor progressed were: bloody ascites (56%) and shock (72%), both attributed to local (peritoneal) tumor invasion. CONCLUSION: The E0771 metastatic breast cancer model, which mimics the human disease, should be useful in testing new treatments against this disease and/or in examining the metastatic process.
BACKGROUND:Breast cancer treatments are most effective when initiated early, with very poor efficacy against metastatic disease. In seeking a readily metastasizing mousebreast cancer model to facilitate the search for effective therapies, E0771 medullary adenocarcinomas implanted subcutaneously in syngeneic C57BL/6 mice were studied. MATERIALS AND METHODS: Standard pathological, histological and immunological methodologies were used. RESULTS: The aggressive estrogen receptor-positive tumor invaded locally into the peritoneal cavity in 56% of mice, as well as metastasizing to the lungs in 52% of mice. The metastasis was a spontaneous event and immunosuppression was seen (e.g. generation of lyphokine activated killer cells and allogeneic cytotoxic T lymphocytes cytolytic activities ex vivo were suppressed). Other pathological events noted as the tumor progressed were: bloody ascites (56%) and shock (72%), both attributed to local (peritoneal) tumor invasion. CONCLUSION: The E0771 metastatic breast cancer model, which mimics the human disease, should be useful in testing new treatments against this disease and/or in examining the metastatic process.
Authors: Shane J F Cronin; Corey Seehus; Adelheid Weidinger; Sebastien Talbot; Sonja Reissig; Markus Seifert; Yann Pierson; Eileen McNeill; Maria Serena Longhi; Bruna Lenfers Turnes; Taras Kreslavsky; Melanie Kogler; David Hoffmann; Melita Ticevic; Débora da Luz Scheffer; Luigi Tortola; Domagoj Cikes; Alexander Jais; Manu Rangachari; Shuan Rao; Magdalena Paolino; Maria Novatchkova; Martin Aichinger; Lee Barrett; Alban Latremoliere; Gerald Wirnsberger; Guenther Lametschwandtner; Meinrad Busslinger; Stephen Zicha; Alexandra Latini; Simon C Robson; Ari Waisman; Nick Andrews; Michael Costigan; Keith M Channon; Guenter Weiss; Andrey V Kozlov; Mark Tebbe; Kai Johnsson; Clifford J Woolf; Josef M Penninger Journal: Nature Date: 2018-11-07 Impact factor: 49.962
Authors: Jane McHowat; Gail Gullickson; Richard G Hoover; Janhavi Sharma; John Turk; Jacki Kornbluth Journal: Am J Physiol Cell Physiol Date: 2011-01-12 Impact factor: 4.249
Authors: Maroof Hasan; Vijay K Gonugunta; Nicole Dobbs; Aktar Ali; Guillermo Palchik; Maria A Calvaruso; Ralph J DeBerardinis; Nan Yan Journal: Proc Natl Acad Sci U S A Date: 2017-01-09 Impact factor: 11.205
Authors: Jaina M Patel; Vincent F Vartabedian; Erica N Bozeman; Brianne E Caoyonan; Sanjay Srivatsan; Christopher D Pack; Paulami Dey; Martin J D'Souza; Lily Yang; Periasamy Selvaraj Journal: Biomaterials Date: 2015-09-28 Impact factor: 12.479