Literature DB >> 16311804

Rapid deprotection of N-Boc amines by TFA combined with freebase generation using basic ion-exchange resins.

Natarajan Srinivasan1, Alexander Yurek-George, A Ganesan.   

Abstract

The deprotection of N-Boc amines was rapidly accomplished using 5 equivalents of TFA in methylene chloride in a focused microwave instrument with irradiation at 60 degrees C for 30 min. The freebase amines are then obtained by scavenging the crude reaction mixture with the basic Amberlyst A-21 ion-exchange resin. This procedure is suitable for the parallel deprotection of N-Boc amines.

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Year:  2005        PMID： 16311804     DOI： 10.1007/s11030-005-4386-8

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  1 in total

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