Literature DB >> 16311710

High-resolution SNP map of ASPN, a susceptibility gene for osteoarthritis.

Aritoshi Iida1, Hideki Kizawa2, Yusuke Nakamura3,4, Shiro Ikegawa2.   

Abstract

Osteoarthritis (OA) is a very common bone and joint disease characterized by breakdown of cartilage in the joint. We recently found that an aspartic-acid repeat polymorphism of the asporin gene (ASPN) on chromosome 9 is associated with susceptibility to OA in Japanese. We provide here a high-resolution single nucleotide polymorphism (SNP) map within a 33.4-kb genomic region containing ASPN. A total of 19 SNPs were isolated from the region by systematic screening using 48 Japanese patients with OA: 7 SNPs in the 5' flanking region, 8 in introns, and 4 in the 3' untranslated region. Nine SNPs were novel. This high-resolution SNP map will be a useful resource for analyzing genes associated with OA and other bone and joint diseases.

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Year:  2005        PMID： 16311710     DOI： 10.1007/s10038-005-0337-6

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  10 in total

1.  Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion.

Authors:  J T den Dunnen; S E Antonarakis
Journal:  Hum Mutat       Date:  2000       Impact factor: 4.878

2.  Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism.

Authors:  Hisanori Haga; Ryo Yamada; Yozo Ohnishi; Yusuke Nakamura; Toshihiro Tanaka
Journal:  J Hum Genet       Date:  2002       Impact factor: 3.172

3.  Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.

Authors:  S P Henry; M Takanosu; T C Boyd; P M Mayne; H Eberspaecher; W Zhou; B de Crombrugghe; M Hook; R Mayne
Journal:  J Biol Chem       Date:  2001-01-10       Impact factor: 5.157

4.  Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.

Authors:  P Lorenzo; A Aspberg; P Onnerfjord; M T Bayliss; P J Neame; D Heinegard
Journal:  J Biol Chem       Date:  2001-01-10       Impact factor: 5.157

5.  Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome.

Authors:  Enid R Neptune; Pamela A Frischmeyer; Dan E Arking; Loretha Myers; Tracie E Bunton; Barbara Gayraud; Francesco Ramirez; Lynn Y Sakai; Harry C Dietz
Journal:  Nat Genet       Date:  2003-02-24       Impact factor: 38.330

6.  Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease.

Authors:  R Yamada; T Tanaka; M Unoki; T Nagai; T Sawada; Y Ohnishi; T Tsunoda; M Yukioka; A Maeda; K Suzuki; H Tateishi; T Ochi; Y Nakamura; K Yamamoto
Journal:  Am J Hum Genet       Date:  2001-02-14       Impact factor: 11.025

7.  Fine-scale SNP map of an 11-kb genomic region at 22q13.1 containing the galectin-1 gene.

Authors:  Aritoshi Iida; Kouichi Ozaki; Toshihiro Tanaka; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-12-10       Impact factor: 3.172

8.  An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.

Authors:  Hideki Kizawa; Ikuyo Kou; Aritoshi Iida; Akihiro Sudo; Yoshinari Miyamoto; Akira Fukuda; Akihiko Mabuchi; Akihiro Kotani; Akira Kawakami; Seizo Yamamoto; Atsumasa Uchida; Kozo Nakamura; Kohei Notoya; Yusuke Nakamura; Shiro Ikegawa
Journal:  Nat Genet       Date:  2005-01-09       Impact factor: 38.330

9.  Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease.

Authors:  W A Border; N A Noble; T Yamamoto; J R Harper; Y u Yamaguchi; M D Pierschbacher; E Ruoslahti
Journal:  Nature       Date:  1992-11-26       Impact factor: 49.962

10.  Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney.

Authors:  Y Isaka; D K Brees; K Ikegaya; Y Kaneda; E Imai; N A Noble; W A Border
Journal:  Nat Med       Date:  1996-04       Impact factor: 53.440
  10 in total
  5 in total

1.  Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells.

Authors:  Jing Sun; Ting Zhang; Panpan Zhang; Linlin Lv; Yanzhi Wang; Jing Zhang; Shu Li
Journal:  J Mol Histol       Date:  2014-07-20       Impact factor: 2.611

2.  Possible association of single nucleotide polymorphisms in the 3' untranslated region of HOXB9 with acetabular overcoverage.

Authors:  T Sekimoto; S Kurogi; T Funamoto; T Ota; S Watanabe; T Sakamoto; H Hamada; E Chosa
Journal:  Bone Joint Res       Date:  2015-04       Impact factor: 5.853

3.  Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes.

Authors:  Kadir Oznam; Duygu Yasar Sirin; Ibrahim Yilmaz; Yasin Emre Kaya; Mehmet Isyar; Seyit Ali Gumustas; Hanefi Ozbek; Semih Akkaya; Arda Kayhan; Mahir Mahirogullari
Journal:  J Orthop Surg Res       Date:  2017-06-26       Impact factor: 2.359

4.  Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc.

Authors:  Helen E Gruber; Jane A Ingram; Gretchen L Hoelscher; Natalia Zinchenko; Edward N Hanley; Yubo Sun
Journal:  Arthritis Res Ther       Date:  2009-03-27       Impact factor: 5.156

5.  Association between EN1 rs4144782 and susceptibility of knee osteoarthritis: A case-control study.

Authors:  Haohuan Li; Xiaolong Zhang; Yiping Cao; Song Hu; Fei Peng; Jianlin Zhou; Jianping Li
Journal:  Oncotarget       Date:  2017-05-30
  5 in total

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