Literature DB >> 16310787

Localization of the nuclear receptor CAR at the cell membrane of mouse liver.

Chika Koike1, Rick Moore, Masahiko Negishi.   

Abstract

The nuclear receptor constitutive active/androstane receptor CAR is a drug-sensing transcription factor. Upon activation by various drugs such as phenobarbital (PB), CAR translocates from the cytoplasm into the nucleus to regulate the genes that encode enzymes and proteins involved in hepatic metabolism. Here, we have shown the presence of CAR at the cell membrane of mouse livers, using Car+/+ and Car-/- mice. Levels of the cell membrane CAR increased after PB treatment. The CAR exists as a large approximately 160 kDa complex. Thus, CAR undergoes PB-induced translocation to the cell membrane, indicating that CAR may exert a non-genomic action.

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Year:  2005        PMID： 16310787     DOI： 10.1016/j.febslet.2005.10.070

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.

Authors:  J P Hernandez; L C Mota; W S Baldwin
Journal:  Curr Pharmacogenomics Person Med       Date:  2009-06-01

2.  Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.

Authors:  U A Argikar; K Senekeo-Effenberger; E E Larson; R H Tukey; R P Remmel
Journal:  Xenobiotica       Date:  2009-11       Impact factor: 1.908

3.  Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.

Authors:  Xueqian Wang; Destiny B Sykes; David S Miller
Journal:  Mol Pharmacol       Date:  2010-06-14       Impact factor: 4.436

Review 4.  Activation of xenobiotic receptors: driving into the nucleus.

Authors:  Haishan Li; Hongbing Wang
Journal:  Expert Opin Drug Metab Toxicol       Date:  2010-04       Impact factor: 4.481

Review 5.  CAR and PXR: the xenobiotic-sensing receptors.

Authors:  Yoav E Timsit; Masahiko Negishi
Journal:  Steroids       Date:  2006-12-20       Impact factor: 2.668

6.  Global liver proteomics of rats exposed for 5 days to phenobarbital identifies changes associated with cancer and with CYP metabolism.

Authors:  Mary B Dail; L Allen Shack; Janice E Chambers; Shane C Burgess
Journal:  Toxicol Sci       Date:  2008-09-16       Impact factor: 4.849

7.  Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.

Authors:  Fardin Hosseinpour; Yoav Timsit; Chika Koike; Kenji Matsui; Yukio Yamamoto; Rick Moore; Masahiko Negishi
Journal:  FEBS Lett       Date:  2007-09-21       Impact factor: 4.124

8.  Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver.

Authors:  Joy Sarkar; Chao Qi; Dongsheng Guo; Mohamed R Ahmed; Yuzhi Jia; Nobuteru Usuda; Navin Viswakarma; M Sambasiva Rao; Janardan K Reddy
Journal:  Gene Expr       Date:  2007

9.  Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.

Authors:  Yoav E Timsit; Masahiko Negishi
Journal:  PLoS One       Date:  2014-05-02       Impact factor: 3.240

Review 10.  Enteric Microbiota⁻Gut⁻Brain Axis from the Perspective of Nuclear Receptors.

Authors:  Kalina Duszka; Walter Wahli
Journal:  Int J Mol Sci       Date:  2018-07-28       Impact factor: 5.923
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