Cécile Delcourt1, Annie Lacroux, Isabelle Carrière. 1. Institut National de la Santé et de la Recherche Médicale, Research Unit U593 for Epidemiology, Public Health and Development, Université Victor Segalen Bordeaux 2, Bordeaux, France. delcourt@montp.inserm.fr
Abstract
PURPOSE: To assess the 3-year incidence of age-related macular degeneration (AMD) in a French population. DESIGN: The "Pathologies Oculaires Liées à l'Age" (POLA) Study, a population-based prospective cohort study. METHODS: Retinal photographs were graded according to the international classification. Early age-related maculopathy (ARM) was defined by the presence of (1) soft indistinct drusen (>125 microm) and/or (2) soft distinct drusen (>125 microm) associated with pigmentary abnormalities. RESULTS: The 3-year incidence of AMD was 0.49% (95% confidence interval [CI]: 0.13 to 0.85) and increased significantly with age, reaching 3.41% (95% CI: 0 to 7.2) in participants aged 80 years or more. After adjustment for age, eyes with early ARM at baseline were 78 times more at risk of developing AMD than eyes without early ARM (OR = 78.4, 95% CI: 14.6 to 420.1). CONCLUSIONS: This study confirms that AMD develops mainly in subjects aged 80 years or older, and in subjects with early ARM.
PURPOSE: To assess the 3-year incidence of age-related macular degeneration (AMD) in a French population. DESIGN: The "Pathologies Oculaires Liées à l'Age" (POLA) Study, a population-based prospective cohort study. METHODS: Retinal photographs were graded according to the international classification. Early age-related maculopathy (ARM) was defined by the presence of (1) soft indistinct drusen (>125 microm) and/or (2) soft distinct drusen (>125 microm) associated with pigmentary abnormalities. RESULTS: The 3-year incidence of AMD was 0.49% (95% confidence interval [CI]: 0.13 to 0.85) and increased significantly with age, reaching 3.41% (95% CI: 0 to 7.2) in participants aged 80 years or more. After adjustment for age, eyes with early ARM at baseline were 78 times more at risk of developing AMD than eyes without early ARM (OR = 78.4, 95% CI: 14.6 to 420.1). CONCLUSIONS: This study confirms that AMD develops mainly in subjects aged 80 years or older, and in subjects with early ARM.
Authors: Paul P Connell; Pearse A Keane; Evelyn C O'Neill; Rasha W Altaie; Edward Loane; Kumari Neelam; John M Nolan; Stephen Beatty Journal: J Ophthalmol Date: 2009-09-06 Impact factor: 1.909
Authors: Andrew Bastawrous; Wanjiku Mathenge; Tunde Peto; Nisha Shah; Kevin Wing; Hillary Rono; Helen A Weiss; David Macleod; Allen Foster; Matthew Burton; Hannah Kuper Journal: JAMA Ophthalmol Date: 2017-06-01 Impact factor: 7.389
Authors: Caroline Brandl; Felix Günther; Martina E Zimmermann; Kathrin I Hartmann; Gregor Eberlein; Teresa Barth; Thomas W Winkler; Birgit Linkohr; Margit Heier; Annette Peters; Jeany Q Li; Robert P Finger; Horst Helbig; Bernhard H F Weber; Helmut Küchenhoff; Arthur Mueller; Klaus J Stark; Iris M Heid Journal: BMJ Open Ophthalmol Date: 2022-01-04
Authors: Christina A Korb; Hisham Elbaz; Alexander K Schuster; Stefan Nickels; Katharina A Ponto; Andreas Schulz; Philipp S Wild; Thomas Münzel; Manfred E Beutel; Irene Schmidtmann; Karl J Lackner; Tunde Peto; Norbert Pfeiffer Journal: Graefes Arch Clin Exp Ophthalmol Date: 2021-08-23 Impact factor: 3.117