BACKGROUND/AIMS: Egypt has the highest prevalence of Hepatitis C Virus (HCV) in the world, apparently due to mass parenteral antischistosomal therapy. Estimating the future burden of HCV in Egypt is important to support health policies to combat the epidemic. METHODS: A previous back calculation model was adapted to the situation in Egypt. It combines a model of the natural history of HCV infections with available epidemiological data to back calculate the past HCV incidence from observed 1980-1999 hepatocellular carcinoma (HCC) mortality. In turn, the HCV-related mortality burden is projected in the future due to pre-2000 infections. RESULTS: Compared with the observed number of HCC deaths in 1999, the model predicts a 3.5-fold increase in this mortality in the next 20 years. Globally, the model predicts a 2.4-fold increase in the HCV-related mortality. These predictions do not take into account the new infections that may occur after 2000, which would still increase the estimated future mortality burden. CONCLUSIONS: HCV-related mortality is expected at least to double in the next 20 years. The use of antiviral therapies can lower these predictions. Efficient prevention policies are needed to avoid these predictions being exceeded.
BACKGROUND/AIMS: Egypt has the highest prevalence of Hepatitis C Virus (HCV) in the world, apparently due to mass parenteral antischistosomal therapy. Estimating the future burden of HCV in Egypt is important to support health policies to combat the epidemic. METHODS: A previous back calculation model was adapted to the situation in Egypt. It combines a model of the natural history of HCV infections with available epidemiological data to back calculate the past HCV incidence from observed 1980-1999 hepatocellular carcinoma (HCC) mortality. In turn, the HCV-related mortality burden is projected in the future due to pre-2000 infections. RESULTS: Compared with the observed number of HCC deaths in 1999, the model predicts a 3.5-fold increase in this mortality in the next 20 years. Globally, the model predicts a 2.4-fold increase in the HCV-related mortality. These predictions do not take into account the new infections that may occur after 2000, which would still increase the estimated future mortality burden. CONCLUSIONS:HCV-related mortality is expected at least to double in the next 20 years. The use of antiviral therapies can lower these predictions. Efficient prevention policies are needed to avoid these predictions being exceeded.
Authors: Radoslav Goldman; Habtom W Ressom; Mohamed Abdel-Hamid; Lenka Goldman; Antai Wang; Rency S Varghese; Yanming An; Christopher A Loffredo; Steven K Drake; Sohair A Eissa; Iman Gouda; Sameera Ezzat; Francoise Seillier Moiseiwitsch Journal: Carcinogenesis Date: 2007-08-27 Impact factor: 4.944
Authors: Radoslav Goldman; Habtom W Ressom; Rency S Varghese; Lenka Goldman; Gregory Bascug; Christopher A Loffredo; Mohamed Abdel-Hamid; Iman Gouda; Sameera Ezzat; Zuzana Kyselova; Yehia Mechref; Milos V Novotny Journal: Clin Cancer Res Date: 2009-02-17 Impact factor: 12.531
Authors: Abdel-Rahman N Zekri; Hanaa M Alam El-Din; Abeer A Bahnassy; Naglaa A Zayed; Waleed S Mohamed; Suzan H El-Masry; Sayed K Gouda; Gamal Esmat Journal: Comp Hepatol Date: 2010-01-05