| Literature DB >> 16309926 |
D Christidis1, D Kalogerakis, T Y Chan, D Mauri, G Alexiou, A Terzoudi.
Abstract
Sudden unexplained/unexpected death (SUDEP) in epilepsy is a major cause of death accounting for 7-17% of the mortality among epileptic patients. Prolongation of QT-interval has been issued as a major mechanism in SUDEP since it is associated with fatal cardiac arrhythmias. This condition may be further precipitated by anti-epileptic treatment. Despite thorough literature research, we did not find any reports suggesting that primidone is responsible for QT-prolongation. On the contrary, all the retrieved reports addressed that the drug shortened QT-interval and corrected signs and symptoms of the underlying disease.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16309926 DOI： 10.1016/j.seizure.2005.10.002
Source DB: PubMed Journal: Seizure ISSN： 1059-1311 Impact factor: 3.184