Literature DB >> 16309882

Chromosomal inversion discovered in C3H/HeJ mice.

Ellen C Akeson1, Leah Rae Donahue, Wesley G Beamer, Kathy L Shultz, Cheryl Ackert-Bicknell, Clifford J Rosen, Jennifer Corrigan, Muriel T Davisson.   

Abstract

Mice of the inbred mouse strain C3H/HeJ have been shown to be homozygous for a chromosomal inversion on Chromosome (Chr) 6. The inversion encompasses about 20% of the chromosome from approximately 73 Mb to approximately 116 Mb. The importance of this finding is that linkage crosses using C3H/HeJ will show no recombination in this region of Chr 6. The inversion has no apparent effect on the phenotype of C3H/HeJ mice and its presence should not affect biological studies; however, use of C3H/HeJ mice for genetic analysis of Chr 6 should be avoided or the results interpreted with the inversion in mind. The inversion has been named In(6)1J (inversion Chr 6, Jackson 1).

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Year:  2005        PMID： 16309882     DOI： 10.1016/j.ygeno.2005.09.022

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  9 in total

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Journal:  Genetics       Date:  2020-10-16       Impact factor: 4.402
  9 in total

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