Literature DB >> 16309468

Mustard: a potential agent of chemical warfare and terrorism.

R N Saladi1, E Smith, A N Persaud.   

Abstract

As one of the most important vesicant agents, the destructive properties of mustards on the skin, eyes and respiratory system, combined with a lack of antidote, makes them effective weapons. Such weapons are inexpensive, easily obtainable and frequently stockpiled. Sulphur mustard (mustard gas) has been used as a chemical warfare agent in at least 10 conflicts. In this article, the use of mustard as a potential agent of chemical warfare and terrorism is outlined. The dose-dependent effects of acute sulphur mustard exposure on the skin, eyes, and respiratory system are described, as well as the possible extents of injuries, the mechanisms of action and the long-term complications. Prevention and management of mustard exposure are briefly discussed. The need for awareness and preparedness in the dermatological community regarding mustard exposure is emphasized.

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Year:  2006        PMID: 16309468     DOI: 10.1111/j.1365-2230.2005.01945.x

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN: 0307-6938            Impact factor:   3.470


  34 in total

1.  2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

Authors:  Stephen Boulware; Tammy Fields; Elizabeth McIvor; K Leslie Powell; Erika L Abel; Karen M Vasquez; Michael C MacLeod
Journal:  Toxicol Appl Pharmacol       Date:  2012-06-23       Impact factor: 4.219

2.  Acute corneal injury in rabbits following nitrogen mustard ocular exposure.

Authors:  Dinesh G Goswami; Rama Kant; David A Ammar; Dileep Kumar; Robert W Enzenauer; J Mark Petrash; Neera Tewari-Singh; Rajesh Agarwal
Journal:  Exp Mol Pathol       Date:  2019-06-21       Impact factor: 3.362

3.  Sulfur mustard induces immune sensitization in hairless guinea pigs.

Authors:  Neerad C Mishra; Jules Rir-sima-ah; Thomas March; Waylon Weber; Janet Benson; Richard Jaramillo; Jean-Clare Seagrave; Gregory Schultz; Gary Grotendorst; Mohan Sopori
Journal:  Int Immunopharmacol       Date:  2009-11-01       Impact factor: 4.932

4.  Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries.

Authors:  Anil K Jain; Neera Tewari-Singh; Swetha Inturi; David J Orlicky; Carl W White; Rajesh Agarwal
Journal:  Toxicology       Date:  2014-03-12       Impact factor: 4.221

5.  Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard.

Authors:  Yoke-Chen Chang; James D Wang; Rita A Hahn; Marion K Gordon; Laurie B Joseph; Diane E Heck; Ned D Heindel; Sherri C Young; Patrick J Sinko; Robert P Casillas; Jeffrey D Laskin; Debra L Laskin; Donald R Gerecke
Journal:  Toxicol Appl Pharmacol       Date:  2014-08-13       Impact factor: 4.219

Review 6.  Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite.

Authors:  Dinesh Giri Goswami; Rajesh Agarwal; Neera Tewari-Singh
Journal:  Toxicol Lett       Date:  2017-11-12       Impact factor: 4.372

Review 7.  Corneal toxicity induced by vesicating agents and effective treatment options.

Authors:  Dinesh G Goswami; Neera Tewari-Singh; Rajesh Agarwal
Journal:  Ann N Y Acad Sci       Date:  2016-06-21       Impact factor: 5.691

8.  Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice.

Authors:  Neera Tewari-Singh; Sumeet Rana; Mallikarjuna Gu; Arttatrana Pal; David J Orlicky; Carl W White; Rajesh Agarwal
Journal:  Toxicol Sci       Date:  2008-12-15       Impact factor: 4.849

9.  Topical nitrogen mustard exposure causes systemic toxic effects in mice.

Authors:  Dinesh G Goswami; Dileep Kumar; Neera Tewari-Singh; David J Orlicky; Anil K Jain; Rama Kant; Raymond C Rancourt; Deepanshi Dhar; Swetha Inturi; Chapla Agarwal; Carl W White; Rajesh Agarwal
Journal:  Exp Toxicol Pathol       Date:  2014-12-04

10.  Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries.

Authors:  Neera Tewari-Singh; Anil K Jain; Swetha Inturi; David A Ammar; Chapla Agarwal; Puneet Tyagi; Uday B Kompella; Robert W Enzenauer; J Mark Petrash; Rajesh Agarwal
Journal:  Toxicol Appl Pharmacol       Date:  2012-07-24       Impact factor: 4.219

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