| Literature DB >> 16308430 |
R Vazan1, D Pancza, I Béder, J Styk.
Abstract
The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed protective effect of melatonin on reperfusion-induced arrhythmias--arrhythmia score was significantly lower as well as the total time of arrhythmias duration was significantly shorter in melatonin group than in controls. On the other hand, post-ischemic recovering of contractility was significantly reduced in melatonin group.Entities:
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Year: 2005 PMID： 16308430
Source DB: PubMed Journal: Gen Physiol Biophys ISSN： 0231-5882 Impact factor: 1.512