Literature DB >> 16308241

Failure of interferon alpha-2b in a patient with West Nile virus meningoencephalitis and acute flaccid paralysis.

Kirk M Chan-Tack1, Graeme Forrest.   

Abstract

WNV infection can cause meningoencephalitis (MNE) and acute flaccid paralysis (AFP). Both syndromes are associated with high morbidity and mortality. Interferon alpha-2b (IFN-alpha-2b) inhibits WNV replication in vitro. To date, 5 patients with WNV-CNS disease have recovered neurologic function with IFN-alpha-2b. We report the first failure of IFN-alpha-2b in the treatment of WNV-MNE-AFP.

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Year:  2005        PMID： 16308241     DOI： 10.1080/00365540500262690

Source DB:  PubMed          Journal:  Scand J Infect Dis        ISSN： 0036-5548


  23 in total

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2.  Why the West in West Nile virus infections?

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Review 4.  Innate immune escape by Dengue and West Nile viruses.

Authors:  Michaela U Gack; Michael S Diamond
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Review 5.  West Nile virus.

Authors:  Shannan L Rossi; Ted M Ross; Jared D Evans
Journal:  Clin Lab Med       Date:  2010-03       Impact factor: 1.935

6.  Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling.

Authors:  Jared D Evans; Christoph Seeger
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

7.  Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response.

Authors:  Penny Clarke; J Smith Leser; Eamon D Quick; Kalen R Dionne; J David Beckham; Kenneth L Tyler
Journal:  J Virol       Date:  2013-11-06       Impact factor: 5.103

8.  Antiviral effect of interferon lambda against West Nile virus.

Authors:  Dongling Ma; Dong Jiang; Min Qing; Jessica M Weidner; Xiaowang Qu; Haitao Guo; Jinhong Chang; Baohua Gu; Pei-Yong Shi; Timothy M Block; Ju-Tao Guo
Journal:  Antiviral Res       Date:  2009-04-01       Impact factor: 5.970

9.  Virus and host determinants of West Nile virus pathogenesis.

Authors:  Michael S Diamond
Journal:  PLoS Pathog       Date:  2009-06-26       Impact factor: 6.823

10.  Successful treatment with intravenous immunoglobulin of acute flaccid paralysis caused by west nile virus.

Authors:  Mohammad Sami Walid; Fade Aziz Mahmoud
Journal:  Perm J       Date:  2009
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