Literature DB >> 16307528

Natural products as angiogenesis modulators.

K A El Sayed1.   

Abstract

Cancer remains one of the major causes of death worldwide. Anti-angiogenic therapy is one of the new approaches to anticancer therapy. Out of 22 angiogenesis inhibitors currently under clinical trials there are 11 natural products or were modeled on a natural product parent. This review shows the potential of natural products for the discovery of new anti-angiogenic leads.

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Year:  2005        PMID： 16307528     DOI： 10.2174/138955705774575291

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  6 in total

1.  Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition.

Authors:  Wen-wen Lv; Si-ning Qin; Cong-qin Chen; Jin-jie Zhang; Tian-shu Ren; Yong-nan Xu; Qing-chun Zhao
Journal:  Acta Pharmacol Sin       Date:  2014-05       Impact factor: 6.150

2.  Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis.

Authors:  C S Coleman; J P Rocetes; D J Park; C J Wallick; B J Warn-Cramer; K Michel; R Dudler; A S Bachmann
Journal:  Cell Prolif       Date:  2006-12       Impact factor: 6.831

3.  Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation.

Authors:  Kwan-Hyun Kim; Hyo-Jung Lee; Soo-Jin Jeong; Hyo-Jeong Lee; Eun-Ok Lee; Hyun-Seok Kim; Yong Zhang; Shi-Yong Ryu; Min-Ho Lee; Junxuan Lü; Sung-Hoon Kim
Journal:  Pharm Res       Date:  2010-11-10       Impact factor: 4.200

4.  Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.

Authors:  Chih-Ya Wang; An-Chi Tsai; Chieh-Yu Peng; Ya-Ling Chang; Kuo-Hsiung Lee; Che-Ming Teng; Shiow-Lin Pan
Journal:  PLoS One       Date:  2012-02-16       Impact factor: 3.240

5.  Dose Dependent Dual Effect of Baicalin and Herb Huang Qin Extract on Angiogenesis.

Authors:  Dongqing Zhu; Shanshan Wang; John Lawless; Jianchen He; Zhengui Zheng
Journal:  PLoS One       Date:  2016-11-30       Impact factor: 3.240

6.  Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa.

Authors:  Flávia C M Lopes; Ana Rocha; Ana Pirraco; Luis O Regasini; Dulce H S Silva; Vanderlan S Bolzani; Isabel Azevedo; Iracilda Z Carlos; Raquel Soares
Journal:  BMC Complement Altern Med       Date:  2009-05-22       Impact factor: 3.659
  6 in total

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