Literature DB >> 16304181

Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge.

Martina Ulrich1, Cordula Albers, Jan-Georg Möller, Axel Dalhoff, Gisela Korfmann, Frank Künkele, Gerd Döring.   

Abstract

We determined the protective effect of moxifloxacin, azithromycin, and amoxicillin against Streptococcus pneumoniae infection of respiratory cells. Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective.

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Year:  2005        PMID： 16304181      PMCID： PMC1315938          DOI： 10.1128/AAC.49.12.5119-5122.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Concentrations of moxifloxacin in serum and pulmonary compartments following a single 400 mg oral dose in patients undergoing fibre-optic bronchoscopy.

Authors:  A Soman; D Honeybourne; J Andrews; G Jevons; R Wise
Journal:  J Antimicrob Chemother       Date:  1999-12       Impact factor: 5.790

2.  Efficacy and safety of sequential moxifloxacin for treatment of community-acquired pneumonia associated with atypical pathogens.

Authors:  G Hoeffken; D Talan; L S Larsen; S Peloquin; S H Choudhri; D Haverstock; P Jackson; D Church
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2004-10       Impact factor: 3.267

3.  Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells.

Authors:  A Pascual; I García; S Ballesta; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

4.  Penetration of moxifloxacin into peripheral compartments in humans.

Authors:  M Müller; H Stass; M Brunner; J G Möller; E Lackner; H G Eichler
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

5.  Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model.

Authors:  M E Klepser; E J Ernst; C R Petzold; P Rhomberg; G V Doern
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

Review 6.  Pharmacokinetics and pharmacodynamics of fluoroquinolones in the respiratory tract.

Authors:  R Wise; D Honeybourne
Journal:  Eur Respir J       Date:  1999-07       Impact factor: 16.671

Review 7.  Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies.

Authors:  Peter Ball; Ralf Stahlmann; Rolf Kubin; Shurjeel Choudhri; Robert Owens
Journal:  Clin Ther       Date:  2004-07       Impact factor: 3.393

8.  Capillary electrophoresis with laser-induced fluorescence: a routine method to determine moxifloxacin in human body fluids in very small sample volumes.

Authors:  J G Möller; H Stass; R Heinig; G Blaschke
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1998-09-25

9.  Antimicrobial resistance of Streptococcus pneumoniae isolates of outpatients in Germany, 1999-2000.

Authors:  Ralf René Reinert; Rudolf Lütticken; Susanne Reinert; Adnan Al-Lahham; Sebastian Lemmen
Journal:  Chemotherapy       Date:  2004-09-03       Impact factor: 2.544

10.  Three-dimensional human airway epithelial cell cultures.

Authors:  M Ulrich; G Döring
Journal:  J Cyst Fibros       Date:  2004-08       Impact factor: 5.482
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  2 in total

1.  Transplacental transfer of Azithromycin and its use for eradicating intra-amniotic ureaplasma infection in a primate model.

Authors:  Edward P Acosta; Peta L Grigsby; Kajal B Larson; Amanda M James; Mary C Long; Lynn B Duffy; Ken B Waites; Miles J Novy
Journal:  J Infect Dis       Date:  2013-10-31       Impact factor: 5.226

2.  Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates.

Authors:  Luanne Hall-Stoodley; Laura Nistico; Karthik Sambanthamoorthy; Bethany Dice; Duc Nguyen; William J Mershon; Candice Johnson; Fen Ze Hu; Paul Stoodley; Garth D Ehrlich; J Christopher Post
Journal:  BMC Microbiol       Date:  2008-10-08       Impact factor: 3.605
  2 in total

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