Effect of material ionicity on the performance of daily disposable contact lenses.

The surface of hydrophilic contact lenses is intrinsically hydrophobic. Biocompatibility requires the contact lens surface to be coated with a lipoproteinic biofilm produced by the ocular secretion. For daily disposable modality of wear it is essential that biocompatibility, clinically represented by good in vivo wettability and subjective acceptance, is achieved as quickly as possible following insertion, as the process needs to be repeated daily. It has been hypothesised that non-ionic materials will not achieve biocompatibility as rapidly as ionic materials owing to the latter's ability to attract high levels of adsorbed proteins. The current investigation was a double-masked crossover study that evaluated, over 1 week of wear, a new non-ionic material (Nelfilcon A) and a current ionic material (Etafilcon A) under daily disposable modality. The results obtained showed that overall, both contact lens materials achieved good in vivo tear stability over the first 30 min of wear and good subjective acceptance that remained stable over the period of wear. The results obtained demonstrate that a non-ionic material can achieve rapid biocompatibility and subjective acceptance in a similar manner to an ionic material.