| Literature DB >> 16303311 |
Hong Bin Zou1, Sheng Yi Dong, Chang Xin Zhou, Li Hong Hu, Yi Hang Wu, Hai Bo Li, Jing Xu Gong, Lian Li Sun, Xiu Mei Wu, Hua Bai, Bo Tao Fan, Xiao Jiang Hao, Joachim Stöckigt, Yu Zhao.
Abstract
Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed on six human tumor cell lines such as PC-3, CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 microM, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template.Entities:
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Year: 2005 PMID： 16303311 DOI： 10.1016/j.bmc.2005.10.056
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641