Literature DB >> 16303154

l-DOPA improves odor discrimination learning in rats.

Michelle Pavlis1, Casara Feretti, Alan Levy, Nita Gupta, Christiane Linster.   

Abstract

Using a forced-choice odor discrimination task in rats, we show here that intraperitoneal injections of l-DOPA improve rats' odor discrimination performance in comparison to control rats injected with saline. Although the exact mechanism of l-DOPA and potential action on dopamine receptors remains unclear, the present results indicate that rats injected with the 20-50 mg/kg of l-DOPA performed significantly better in an odor discrimination task than did control rats. In addition, we observed a significant correlation between the concentration of l-DOPA and odor discrimination performance.

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Year:  2005        PMID： 16303154     DOI： 10.1016/j.physbeh.2005.09.011

Source DB:  PubMed          Journal:  Physiol Behav        ISSN： 0031-9384


  13 in total

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