Literature DB >> 16303088

Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview.

Stefanie N Vogel1, Agnes A Awomoyi, Prasad Rallabhandi, Andrei E Medvedev.   

Abstract

In this overview, we will present current information on known mutations in the TLR4 signaling pathway that have been associated with increased susceptibility to disease. To date, mutations in the extracellular domain of TLR4 itself, IRAK-4, NEMO (IKK gamma), and I kappa B alpha have been identified and profoundly affect the host response to infection.

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Year:  2005        PMID： 16303088     DOI： 10.1179/096805105X58724

Source DB:  PubMed          Journal:  J Endotoxin Res        ISSN： 0968-0519


  12 in total

1.  Toll-like receptor 4 polymorphisms in dengue virus-infected children.

Authors:  Kis Djamiatun; Bart Ferwerda; Mihai G Netea; André J A M van der Ven; Wil M V Dolmans; Sultana M H Faradz
Journal:  Am J Trop Med Hyg       Date:  2011-08       Impact factor: 2.345

2.  The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

Authors:  Leandra Figueroa; Yanbao Xiong; Chang Song; Wenji Piao; Stefanie N Vogel; Andrei E Medvedev
Journal:  J Immunol       Date:  2012-04-02       Impact factor: 5.422

3.  Lipopolysaccharides belonging to different Salmonella serovars are differentially capable of activating Toll-like receptor 4.

Authors:  Daniela Chessa; Luisella Spiga; Nicola De Riu; Paola Delaconi; Vittorio Mazzarello; Giulia Ganau; Salvatore Rubino
Journal:  Infect Immun       Date:  2014-08-18       Impact factor: 3.441

4.  Sepsis: Something old, something new, and a systems view.

Authors:  Rami Namas; Ruben Zamora; Rajaie Namas; Gary An; John Doyle; Thomas E Dick; Frank J Jacono; Ioannis P Androulakis; Gary F Nieman; Steve Chang; Timothy R Billiar; John A Kellum; Derek C Angus; Yoram Vodovotz
Journal:  J Crit Care       Date:  2011-07-27       Impact factor: 3.425

Review 5.  Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.

Authors:  Andrei E Medvedev
Journal:  J Interferon Cytokine Res       Date:  2013-05-15       Impact factor: 2.607

6.  Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.

Authors:  Prasad Rallabhandi; Agnes Awomoyi; Karen E Thomas; Armelle Phalipon; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; Nilofer Qureshi; Marcelo B Sztein; Stefanie N Vogel
Journal:  J Immunol       Date:  2008-01-15       Impact factor: 5.422

7.  Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages.

Authors:  Leah E Cole; Kari Ann Shirey; Eileen Barry; Araceli Santiago; Prasad Rallabhandi; Karen L Elkins; Adam C Puche; Suzanne M Michalek; Stefanie N Vogel
Journal:  Infect Immun       Date:  2007-05-21       Impact factor: 3.441

8.  Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice.

Authors:  Daryl S Spinner; In Soo Cho; Seung Yong Park; Jae Il Kim; Harry C Meeker; Xuemin Ye; Giuseppe Lafauci; Daniel J Kerr; Michael J Flory; Bo Sook Kim; Regina B Kascsak; Thomas Wisniewski; William R Levis; Georgia B Schuller-Levis; Richard I Carp; Eunkyue Park; Richard J Kascsak
Journal:  J Virol       Date:  2008-08-20       Impact factor: 5.103

Review 9.  Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy.

Authors:  Marina A Dobrovolskaia
Journal:  J Control Release       Date:  2015-09-05       Impact factor: 9.776

10.  Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.

Authors:  Norio Matsushima; Takanori Tanaka; Purevjav Enkhbayar; Tomoko Mikami; Masae Taga; Keiko Yamada; Yoshio Kuroki
Journal:  BMC Genomics       Date:  2007-05-21       Impact factor: 3.969
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