| Literature DB >> 16301494 |
C A Maurage1, B Udd, M M Ruchoux, P Vermersch, H Kalimo, R Krahe, A Delacourte, N Sergeant.
Abstract
Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.Entities:
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Year: 2005 PMID： 16301494 DOI： 10.1212/01.wnl.0000184585.93864.4e
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910