| Literature DB >> 16300944 |
Ying Lu1, Zongru Guo, Yanshen Guo, Jun Feng, Fengming Chu.
Abstract
A series of 2-alkoxydihydrocinnamates were synthesized as PPARgamma and PPARalpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARalpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes.Entities:
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Year: 2005 PMID： 16300944 DOI： 10.1016/j.bmcl.2005.10.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823