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Literature DB >> 16299347

Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection.

Thirumalai Ramalingam¹, Patricia Porte, James Lee, T V Rajan.

Abstract

The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16299347 PMCID： PMC1307027 DOI： 10.1128/IAI.73.12.8442-8443.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

22 in total

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Authors: K J Hamann; G J Gleich; J L Checkel; D A Loegering; J W McCall; R L Barker
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3. Leishmania donovani molecules recognized by sera of filaria infected host facilitate filarial infection.

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4. Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis.

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5. Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice.

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Review 10. Immunology of lymphatic filariasis.

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