Literature DB >> 16299338

Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes.

Maryse Letiembre1, Hakim Echchannaoui, Philipp Bachmann, Fabrizia Ferracin, Concepción Nieto, Manuel Espinosa, Regine Landmann.   

Abstract

Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2-/-) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2-/- PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.

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Year:  2005        PMID： 16299338      PMCID： PMC1307087          DOI： 10.1128/IAI.73.12.8397-8401.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Regulation of phagosome maturation by signals from toll-like receptors.

Authors:  J Magarian Blander; Ruslan Medzhitov
Journal:  Science       Date:  2004-05-14       Impact factor: 47.728

2.  An improved GFP cloning cassette designed for prokaryotic transcriptional fusions.

Authors:  W G Miller; S E Lindow
Journal:  Gene       Date:  1997-06-03       Impact factor: 3.688

3.  Genetic regulation of maltosaccharide utilization in Pneumococcus.

Authors:  S Lacks
Journal:  Genetics       Date:  1968-12       Impact factor: 4.562

4.  Exudation primes human and guinea pig neutrophils for subsequent responsiveness to the chemotactic peptide N-formylmethionylleucylphenylalanine and increases complement component C3bi receptor expression.

Authors:  W Zimmerli; B Seligmann; J I Gallin
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

5.  Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils.

Authors:  M B Hampton; A J Kettle; C C Winterbourn
Journal:  Infect Immun       Date:  1996-09       Impact factor: 3.441

6.  FACS-optimized mutants of the green fluorescent protein (GFP).

Authors:  B P Cormack; R H Valdivia; S Falkow
Journal:  Gene       Date:  1996       Impact factor: 3.688

7.  Pathogenesis of foreign body infection: description and characteristics of an animal model.

Authors:  W Zimmerli; F A Waldvogel; P Vaudaux; U E Nydegger
Journal:  J Infect Dis       Date:  1982-10       Impact factor: 5.226

8.  Maltose and maltotriose can be formed endogenously in Escherichia coli from glucose and glucose-1-phosphate independently of enzymes of the maltose system.

Authors:  K Decker; R Peist; J Reidl; M Kossmann; B Brand; W Boos
Journal:  J Bacteriol       Date:  1993-09       Impact factor: 3.490

9.  Lipoteichoic acid from Staphylococcus aureus is a potent stimulus for neutrophil recruitment.

Authors:  Sonja von Aulock; Siegfried Morath; Lars Hareng; Sylvia Knapp; Kok P M van Kessel; Jos A G van Strijp; Thomas Hartung
Journal:  Immunobiology       Date:  2003       Impact factor: 3.144

10.  Characterization of the Streptococcus pneumoniae maltosaccharide regulator MalR, a member of the LacI-GalR family of repressors displaying distinctive genetic features.

Authors:  A Puyet; A M Ibáñez; M Espinosa
Journal:  J Biol Chem       Date:  1993-12-05       Impact factor: 5.157
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  27 in total

1.  TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae.

Authors:  Katherine S Lee; Charles A Scanga; Eric M Bachelder; Quanyi Chen; Clifford M Snapper
Journal:  Cell Immunol       Date:  2007-05-22       Impact factor: 4.868

2.  The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2.

Authors:  Goutham Pattabiraman; Rahul Panchal; Andrei E Medvedev
Journal:  J Biol Chem       Date:  2017-04-25       Impact factor: 5.157

Review 3.  Pathogenesis and pathophysiology of pneumococcal meningitis.

Authors:  Barry B Mook-Kanamori; Madelijn Geldhoff; Tom van der Poll; Diederik van de Beek
Journal:  Clin Microbiol Rev       Date:  2011-07       Impact factor: 26.132

4.  Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.

Authors:  Yanna Shen; Ikuo Kawamura; Takamasa Nomura; Kohsuke Tsuchiya; Hideki Hara; Sita R Dewamitta; Shunsuke Sakai; Huixin Qu; Sylvia Daim; Takeshi Yamamoto; Masao Mitsuyama
Journal:  Infect Immun       Date:  2010-04-05       Impact factor: 3.441

5.  Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease.

Authors:  Manuela Puliti; Satoshi Uematsu; Shizuo Akira; Francesco Bistoni; Luciana Tissi
Journal:  Infect Immun       Date:  2009-01-29       Impact factor: 3.441

6.  Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia.

Authors:  A Hsu; D M Aronoff; J Phipps; D Goel; P Mancuso
Journal:  Clin Exp Immunol       Date:  2007-09-05       Impact factor: 4.330

7.  TLR2 promotes macrophage recruitment and Streptococcus pneumoniae clearance during mouse otitis media.

Authors:  Yifei Huang; Zimeng Wang; Chunfang Jin; Lei Wang; Xuemei Zhang; Wenchun Xu; Yun Xiang; Wei Wang; Xiujing He; Yibing Yin; Yujuan He
Journal:  Pediatr Res       Date:  2016-07-27       Impact factor: 3.756

8.  Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.

Authors:  Sandra Ribes; Sandra Ebert; Tommy Regen; Amit Agarwal; Simone C Tauber; Dirk Czesnik; Annette Spreer; Stephanie Bunkowski; Helmut Eiffert; Uwe-Karsten Hanisch; Sven Hammerschmidt; Roland Nau
Journal:  Infect Immun       Date:  2009-11-23       Impact factor: 3.441

9.  Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

Authors:  Alexander A Navarini; Karl S Lang; Admar Verschoor; Mike Recher; Annelies S Zinkernagel; Victor Nizet; Bernhard Odermatt; Hans Hengartner; Rolf M Zinkernagel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-07       Impact factor: 11.205

10.  Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice.

Authors:  George Hajishengallis; Min Wang; Gregory J Bagby; Steve Nelson
Journal:  J Immunol       Date:  2008-09-15       Impact factor: 5.422
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