Literature DB >> 16298513

Detection of p16 promoter methylation in the serum of oral cancer patients.

Y Nakahara1, S Shintani, M Mihara, S Hino, H Hamakawa.   

Abstract

P16 promoter methylation occurs frequently in oral squamous cell carcinoma (OSCC). For the early detection of tumour-related aberrant DNA, we examined p16 methylation using the methylation-specific polymerase chain reaction (MSP) in tumour and serum samples of 17 OSCC patients. Aberrant p16 methylation was detected in 11 (64.7%) cases of primary OSCC. Of these 11 patients, 6 (54.5%) showed the same alteration in their serum. No methylation was found in control groups. Interestingly, DNA was detected in the serum of 3 out of 4 patients with recurrence. These results suggest that the MSP may be a sensitive and useful method for detecting recurrent OSCC.

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Year:  2005        PMID： 16298513     DOI： 10.1016/j.ijom.2005.08.005

Source DB:  PubMed          Journal:  Int J Oral Maxillofac Surg        ISSN： 0901-5027            Impact factor:   2.789


  10 in total

1.  Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells.

Authors:  Jacqueline A Gasche; Jürgen Hoffmann; C Richard Boland; Ajay Goel
Journal:  Int J Cancer       Date:  2011-01-07       Impact factor: 7.396

Review 2.  Epigenetic mechanisms in oral carcinogenesis.

Authors:  Jacqueline A Gasche; Ajay Goel
Journal:  Future Oncol       Date:  2012-11       Impact factor: 3.404

3.  Methylation of the miR-126 gene associated with glioma progression.

Authors:  Hongwei Cui; Yongping Mu; Lei Yu; Ya-guang Xi; Rune Matthiesen; Xiulan Su; Wenjie Sun
Journal:  Fam Cancer       Date:  2016-04       Impact factor: 2.375

4.  A review on salivary genomics and proteomics biomarkers in oral cancer.

Authors:  Franky D Shah; Rasheedunnisa Begum; Bhairavi N Vajaria; Kinjal R Patel; Jayendra B Patel; Shilin N Shukla; Prabhudas S Patel
Journal:  Indian J Clin Biochem       Date:  2011-08-09

5.  Advances and Perspectives in the Molecular Diagnosis of Head and Neck Cancer.

Authors:  Wojciech K Mydlarz; Patrick T Hennessey; Joseph A Califano
Journal:  Expert Opin Med Diagn       Date:  2010-01-01

Review 6.  DNA methylation-based predictors of health: applications and statistical considerations.

Authors:  Paul D Yousefi; Matthew Suderman; Ryan Langdon; Oliver Whitehurst; George Davey Smith; Caroline L Relton
Journal:  Nat Rev Genet       Date:  2022-03-18       Impact factor: 53.242

7.  Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy.

Authors:  Jessica Hier; Olivia Vachon; Allison Bernstein; Iman Ibrahim; Alex Mlynarek; Michael Hier; Moulay A Alaoui-Jamali; Mariana Maschietto; Sabrina Daniela da Silva
Journal:  Sci Rep       Date:  2021-05-11       Impact factor: 4.379

8.  Methylation-mediated molecular dysregulation in clinical oral malignancy.

Authors:  Rebecca Towle; Cathie Garnis
Journal:  J Oncol       Date:  2012-05-07       Impact factor: 4.375

9.  Role of DNA methylation in head and neck cancer.

Authors:  Semra Demokan; Nejat Dalay
Journal:  Clin Epigenetics       Date:  2011-07-09       Impact factor: 6.551

Review 10.  Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma.

Authors:  Buyanbileg Sodnom-Ish; Mi Young Eo; Hoon Myoung; Jong Ho Lee; Soung Min Kim
Journal:  J Korean Assoc Oral Maxillofac Surg       Date:  2022-02-28
  10 in total

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